Evidence map›Paper›PMID 24478497›Full record

ArticleJournal of clinical microbiology2014

Toll-like receptor 2 in serum: a potential diagnostic marker of prosthetic joint infection?

Emanuela Galliera, Lorenzo Drago, Christian Vassena, Carlo Romanò, Monica Gioia Marazzi, Lucia Salcito, Massimiliano M Corsi Romanelli

Abstract read
In one paragraph

Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Bone and Infections: An Osteoimmunological Interplay.International journal of molecular sciences · 2026
    Review
  4. Review
  5. Joint fluid interleukin-6 combined with the neutral polymorphonuclear leukocyte ratio (PMN%) as a diagnostic index for chronic periprosthesis infection after arthroplasty.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2023
    Article
  6. Review
  7. Article
  8. Diagnosing Periprosthetic Joint Infection: a Scoping Review.Current reviews in musculoskeletal medicine · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emanuela GallieraDepartment of Biomedical, Surgical and Oral Science, Università degli Studi di Milano, Milan, Italy.
Lorenzo Drago
Christian Vassena
Carlo Romanò
Monica Gioia Marazzi
Lucia Salcito
Massimiliano M Corsi Romanelli

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prosthetic joint infection (PJI) is a severe complication of arthroplasty and is still lacking diagnostic gold standards. PJI patients display high Toll-like receptor 2 (TLR2) serum levels, correlating with canonical inflammatory markers (C-reactive protein [CRP], interleukin 6 [IL-6], tumor necrosis factor alpha [TNF-α], and IL-1). Therefore, TLR2 serum levels could be considered a new potential diagnostic tool in the early detection of PJI.

Indexed as

AgedAged, 80 and overArthritisArthroplastyBiomarkersEarly DiagnosisHumansMaleMiddle AgedProsthesis-Related InfectionsSerumToll-Like Receptor 2BiomarkersTLR2 protein, humanToll-Like Receptor 2

Identifiers

PMID24478497
PMCPMC3911304

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.