ArticleJournal of clinical microbiology2014
Colorimetric sensor array allows fast detection and simultaneous identification of sepsis-causing bacteria in spiked blood culture.
Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Volatile organic compounds (VOCs) detection for the identification of bacterial infections in clinical wound samples.Talanta · 2025Review
- Isolator-based point-of-care manufacturing: a practical solution for GMP-compliant cell and extracellular vesicles therapy production.Frontiers in bioengineering and biotechnology · 2025Review
- Evaluation of the RevealPathogens (Basel, Switzerland) · 2024Article
- Facile Preparation of TiOSensors (Basel, Switzerland) · 2024Article
- Challenges and Advances in Biomarker Detection for Rapid and Accurate Sepsis Diagnosis: An Electrochemical Approach.Biosensors · 2024Review
- Current Limitations of Staph Infection Diagnostics, and the Role for VOCs in Achieving Culture-Independent Detection.Pathogens (Basel, Switzerland) · 2023Review
- Paper-based sensors for bacteria detection.Nature reviews bioengineering · 2023Review
- Single-Particle Optical Imaging for Ultrasensitive Bioanalysis.Biosensors · 2022Review
- Suggestion for a new bacteriophage genus for the Klebsiella pneumoniae phage vB_KpnS-Carvaje.Current genetics · 2022Article
- 2D nanomaterial sensing array using machine learning for differential profiling of pathogenic microbial taxonomic identification.Mikrochimica acta · 2022Article
- Performance of the Reveal Rapid Antibiotic Susceptibility Testing System on Gram-Negative Blood Cultures at a Large Urban Hospital.Journal of clinical microbiology · 2022Article
- Polymer-based chemical-nose systems for optical-pattern recognition of gut microbiota.Chemical science · 2022Article
- Susceptibility Testing by Volatile Organic Compound Detection Direct from Positive Blood Cultures: A Proof-of-Principle Laboratory Study.Antibiotics (Basel, Switzerland) · 2022Article
- Metabolic preference assay for rapid diagnosis of bloodstream infections.Nature communications · 2022Article
- Pilot Testing of the "Turbidimeter", a Simple, Universal Reader Intended to Complement and Enhance Bacterial Growth Detection in Manual Blood Culture Systems in Low-Resource Settings.Diagnostics (Basel, Switzerland) · 2022Article
- Disposable Paper-Based Biosensors for the Point-of-Care Detection of Hazardous Contaminations-A Review.Biosensors · 2021Review
- Modern Tools for Rapid Diagnostics of Antimicrobial Resistance.Frontiers in cellular and infection microbiology · 2020Review
- Comprehensive volatile metabolic fingerprinting of bacterial and fungal pathogen groups.Journal of breath research · 2018Article
- Syndromic Panel-Based Testing in Clinical Microbiology.Clinical microbiology reviews · 2018Review
- Emerging Microtechnologies and Automated Systems for Rapid Bacterial Identification and Antibiotic Susceptibility Testing.SLAS technology · 2017Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Sepsis is a medical emergency demanding early diagnosis and tailored antimicrobial therapy. Every hour of delay in initiating effective therapy measurably increases patient mortality. Blood culture is currently the reference standard for detecting bloodstream infection, a multistep process which may take one to several days. Here, we report a novel paradigm for earlier detection and the simultaneous identification of pathogens in spiked blood cultures by means of a metabolomic "fingerprint" of the volatile mixture outgassed by the organisms. The colorimetric sensor array provided significantly faster detection of positive blood cultures than a conventional blood culture system (12.1 h versus 14.9 h, P < 0.001) while allowing for the identification of 18 bacterial species with 91.9% overall accuracy within 2 h of growth detection. The colorimetric sensor array also allowed for discrimination between unrelated strains of methicillin-resistant Staphylococcus aureus, indicating that the metabolomic fingerprint has the potential to track nosocomial transmissions. Altogether, the colorimetric sensor array is a promising tool that offers a new paradigm for diagnosing bloodstream infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.