ArticleJournal of clinical microbiology2014
Comparative performances of HIV-1 RNA load assays at low viral load levels: results of an international collaboration.
Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Improved HIV-1 Viral Load Monitoring Capacity Using Pooled Testing With Marker-Assisted Deconvolution.Journal of acquired immune deficiency syndromes (1999) · 2017Pooled it
- Low-level viremia in people with HIV in Ethiopia is associated with subsequent lack of viral suppression and attrition from care.Global health action · 2025Article
- Antiretroviral Therapy Within 2 Years of HIV Acquisition Is Associated With Fewer Viral Blips: A Retrospective Analysis of More Than 20 Years of Data From the US Military HIV Natural History Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- HIV Cerebrospinal Fluid Escape: Interventions for the Management, Current Evidence and Future Perspectives.Tropical medicine and infectious disease · 2025Review
- Risk factors for virologic failure and persistent low-level viremia in people with HIV experiencing low-level viremia: Chongqing ART cohort study, 2019-2023.Frontiers in medicine · 2025Article
- Understanding clinical outcome measures reported in HIV pregnancy studies involving antiretroviral-naive and antiretroviral-experienced women.The Lancet. Infectious diseases · 2023Review
- Maternal plasma and salivary anelloviruses in pregnancy and preterm birth.Frontiers in medicine · 2023Article
- Performance of Xpert HIV-1 viral load test in Senegal: a country of high circulation of CRF02_AG.The Pan African medical journal · 2022Article
- Achieving consistency in measures of HIV-1 viral suppression across countries: derivation of an adjustment based on international antiretroviral treatment cohort data.Journal of the International AIDS Society · 2021Article
- All-Cause Mortality and Serious Non-AIDS Events in Adults With Low-level Human Immunodeficiency Virus Viremia During Combination Antiretroviral Therapy: Results From a Swedish Nationwide Observational Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Observational
- A Comprehensive Genomics Solution for HIV Surveillance and Clinical Monitoring in Low-Income Settings.Journal of clinical microbiology · 2020Article
- Factors associated with high-risk low-level viremia leading to virologic failure: 16-year retrospective study of a Chinese antiretroviral therapy cohort.BMC infectious diseases · 2020Article
- Patterns of detectable viraemia among children and adults with HIV infection taking antiretroviral therapy in Zimbabwe.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2019Article
- Human immunodeficiency virus infection induces lymphoid fibrosis in the BM-liver-thymus-spleen humanized mouse model.JCI insight · 2018Article
- Comparison of the Aptima HIV-1 Quant Dx assay with the COBAS AmpliPrep/COBAS TaqMan HIV-1 v2.0 Test for HIV-1 viral load quantification in plasma samples from HIV-1-infected patients.Health science reports · 2018Article
- GeneXpert HIV-1 quant assay, a new tool for scale up of viral load monitoring in the success of ART programme in India.BMC infectious diseases · 2017Article
- Virological failure and all-cause mortality in HIV-positive adults with low-level viremia during antiretroviral treatment.PloS one · 2017Article
- Point-of-Care Cepheid Xpert HIV-1 Viral Load Test in Rural African Communities Is Feasible and Reliable.Journal of clinical microbiology · 2016Article
- Evaluation of the Aptima(®) HIV-1 Quant Dx assay for HIV-1 RNA viral load detection and quantitation in plasma of HIV-1-infected individuals: A comparison with Abbott RealTime HIV-1 assay.Journal of medical virology · 2016Article
- A Single Quantifiable Viral Load Is Predictive of Virological Failure in Human Immunodeficiency Virus (HIV)-Infected Patients on Combination Antiretroviral Therapy: The Austrian HIV Cohort Study.Open forum infectious diseases · 2016Article
Corrections and comments
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Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low-level viremia during antiretroviral therapy and its accurate measurement are increasingly relevant. Here, we present an international collaboration of 4,221 paired blood plasma viral load (pVL) results from four commercial assays, emphasizing the data with low pVL. The assays compared were the Abbott RealTime assay, the Roche Amplicor assay, and the Roche TaqMan version 1 and version 2 assays. The correlation between the assays was 0.90 to 0.97. However, at a low pVL, the correlation fell to 0.45 to 0.85. The observed interassay concordance was higher when detectability was defined as 200 copies/ml than when it was defined as 50 copies/ml. A pVL of ∼100 to 125 copies/ml by the TaqMan version 1 and version 2 assays corresponded best to a 50-copies/ml threshold with the Amplicor assay. Correlation and concordance between the viral load assays were lower at a low pVL. Clear guidelines are needed on the clinical significance of low-level viremia.
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