ReviewCold Spring Harbor perspectives in medicine2014
Facial and hand allotransplantation.
Review in Cold Spring Harbor perspectives in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Maximizing Neurovascular Outcomes of Facial Transplantation: A Comprehensive Review.Clinical anatomy (New York, N.Y.) · 2026Review
- A Decade of Innovation: A 10-year Institutional Review of Advancements in Vascularized Composite Allotransplantation.Plastic and reconstructive surgery. Global open · 2026Article
- Laryngeal transplantation: from experimental feasibility to multidisciplinary clinical reality.Frontiers in surgery · 2026Review
- Radial Forearm Free Flap: A Modified Technique for Procurement as a Sentinel Skin Flap.Transplantation direct · 2025Article
- Autologous porcine VRAM flap model for VCA research.Frontiers in transplantation · 2024Article
- Cell therapy in vascularized composite allotransplantation.Biomedical journal · 2022Review
- Hand Transplantation-Risks and Benefits.Journal of hand and microsurgery · 2021Review
- Randomized preclinical study of machine perfusion in vascularized composite allografts.The British journal of surgery · 2021Article
- Large Animal Models of Vascularized Composite Allotransplantation: A Review of Immune Strategies to Improve Allograft Outcomes.Frontiers in immunology · 2021Review
- Establishing Photographic Standards for Facial Transplantation: A Systematic Review of the Literature.Plastic and reconstructive surgery. Global open · 2020Article
- Delivery of Rapamycin Using In Situ Forming Implants Promotes Immunoregulation and Vascularized Composite Allograft Survival.Scientific reports · 2019Article
- Composite tissue allotransplantation: opportunities and challenges.Cellular & molecular immunology · 2019Review
- Enhanced Drug Delivery to the Skin Using Liposomes.Plastic and reconstructive surgery. Global open · 2018Article
- The combination of mitomycin-induced blood cells with a temporary treatment of ciclosporin A prolongs allograft survival in vascularized composite allotransplantation.Langenbeck's archives of surgery · 2018Article
- Accommodation and related conditions in vascularized composite allografts.Current opinion in organ transplantation · 2017Review
- Immunological and inflammatory mapping of vascularized composite allograft rejection processes in a rat model.PloS one · 2017Article
- Long-term Tolerance Toward Haploidentical Vascularized Composite Allograft Transplantation in a Canine Model Using Bone Marrow or Mobilized Stem Cells.Transplantation · 2016Article
- Orthotopic Hind Limb Transplantation in the Mouse.Journal of visualized experiments : JoVE · 2016Article
- Emerging Implications for Extracellular Matrix-Based Technologies in Vascularized Composite Allotransplantation.Stem cells international · 2016Review
- Engineered composite tissue as a bioartificial limb graft.Biomaterials · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vascularized composite allotransplantation (VCA) is a novel therapeutic option for treatment of patients suffering from limb loss or severe facial disfigurement. To date, 72 hand and 19 facial transplantations have been performed worldwide. VCA in hand and facial transplantation is a complex procedure requiring a multidisciplinary team approach and extensive surgical planning. Despite good functional outcome, courses after hand and facial transplantation have been complicated by skin rejection. Long-term immunosuppression remains a necessity in VCA for allograft survival. To widen the scope of these quality-of-life-improving procedures, minimization of immunosuppression to limit risks and side effects is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.