ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Cerebellar potentiation and learning a whisker-based object localization task with a time response window.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- The effect of transcranial direct current stimulation on static and dynamic posture control in the elderly: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- PP2B-Dependent Cerebellar Plasticity Sets the Amplitude of the Vestibulo-ocular Reflex during Juvenile Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cerebro-cerebellar networks facilitate learning through feedback decoupling.Nature communications · 2023Article
- Purkinje Cell Activity Resonation Generates Rhythmic Behaviors at the Preferred Frequency of 8 Hz.Biomedicines · 2022Article
- Is Anodal Transcranial Direct Current Stimulation an Effective Ergogenic Technology in Lower Extremity Sensorimotor Control for Healthy Population? A Narrative Review.Brain sciences · 2022Review
- Brain-Inspired Spiking Neural Network Controller for a Neurorobotic Whisker System.Frontiers in neurorobotics · 2022Article
- Region-specific preservation of Purkinje cell morphology and motor behavior in the ATXN1[82Q] mouse model of spinocerebellar ataxia 1.Brain pathology (Zurich, Switzerland) · 2021Article
- Article
- Functional Convergence of Autonomic and Sensorimotor Processing in the Lateral Cerebellum.Cell reports · 2020Article
- WhiskEras: A New Algorithm for Accurate Whisker Tracking.Frontiers in cellular neuroscience · 2020Article
- An automated homecage system for multiwhisker detection and discrimination learning in mice.PloS one · 2020Article
- Neurons of the inferior olive respond to broad classes of sensory input while subject to homeostatic control.The Journal of physiology · 2019Article
- Quasiperiodic rhythms of the inferior olive.PLoS computational biology · 2019Article
- Article
- Early Trajectory Prediction in Elite Athletes.Cerebellum (London, England) · 2018Article
- Serial processing of kinematic signals by cerebellar circuitry during voluntary whisking.Nature communications · 2017Article
- A comparative approach to cerebellar function: insights from electrosensory systems.Current opinion in neurobiology · 2016Review
- Oscillations, Timing, Plasticity, and Learning in the Cerebellum.Cerebellum (London, England) · 2016Review
- Clocks within Clocks: Timing by Coincidence Detection.Current opinion in behavioral sciences · 2016Article
- Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whisker-based object localization requires activation and plasticity of somatosensory and motor cortex. These parts of the cerebral cortex receive strong projections from the cerebellum via the thalamus, but it is unclear whether and to what extent cerebellar processing may contribute to such a sensorimotor task. Here, we subjected knock-out mice, which suffer from impaired intrinsic plasticity in their Purkinje cells and long-term potentiation at their parallel fiber-to-Purkinje cell synapses (L7-PP2B), to an object localization task with a time response window (RW). Water-deprived animals had to learn to localize an object with their whiskers, and based upon this location they were trained to lick within a particular period ("go" trial) or refrain from licking ("no-go" trial). L7-PP2B mice were not ataxic and showed proper basic motor performance during whisking and licking, but were severely impaired in learning this task compared with wild-type littermates. Significantly fewer L7-PP2B mice were able to learn the task at long RWs. Those L7-PP2B mice that eventually learned the task made unstable progress, were significantly slower in learning, and showed deficiencies in temporal tuning. These differences became greater as the RW became narrower. Trained wild-type mice, but not L7-PP2B mice, showed a net increase in simple spikes and complex spikes of their Purkinje cells during the task. We conclude that cerebellar processing, and potentiation in particular, can contribute to learning a whisker-based object localization task when timing is relevant. This study points toward a relevant role of cerebellum-cerebrum interaction in a sophisticated cognitive task requiring strict temporal processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.