ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Differential associative training enhances olfactory acuity in Drosophila melanogaster.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Spacing effect improves generalization in biological and artificial systems.Patterns (New York, N.Y.) · 2026Article
- Cognitive limits of larvalLearning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Pruning deficits of the developingOpen biology · 2022Article
- Dopamine activity in projection neurons regulates short-lasting olfactory approach memory in Drosophila.The European journal of neuroscience · 2022Article
- Pairing-Dependent Plasticity in a Dissected Fly Brain Is Input-Specific and Requires Synaptic CaMKII Enrichment and Nighttime Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- In Search for the Retrievable Memory Trace in an Insect Brain.Frontiers in systems neuroscience · 2022Review
- A Markerless Pose Estimator Applicable to Limbless Animals.Frontiers in behavioral neuroscience · 2022Article
- Article
- Olfactory processing in the lateral horn of Drosophila.Cell and tissue research · 2021Review
- Fruit flies can learn non-elemental olfactory discriminations.Proceedings. Biological sciences · 2020Article
- Spaced Training Forms Complementary Long-Term Memories of Opposite Valence in Drosophila.Neuron · 2020Article
- Dopamine Receptor Dop1R2 Stabilizes Appetitive Olfactory Memory through the Raf/MAPK Pathway inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- One-trial learning in larvalLearning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Reinforcement signaling of punishment versus relief in fruit flies.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Functional architecture of reward learning in mushroom body extrinsic neurons of larval Drosophila.Nature communications · 2018Article
- Aversive gustatory learning and perception in honey bees.Scientific reports · 2018Article
- Associative Learning of Stimuli Paired and Unpaired With Reinforcement: Evaluating Evidence From Maggots, Flies, Bees, and Rats.Frontiers in psychology · 2018Article
- Calcium imaging revealed no modulatory effect on odor-evoked responses of the Drosophila antennal lobe by two populations of inhibitory local interneurons.Scientific reports · 2017Article
- Aversive olfactory associative memory loses odor specificity over time.The Journal of experimental biology · 2017Article
- Behavioral Evidence for Enhanced Processing of the Minor Component of Binary Odor Mixtures in LarvalFrontiers in psychology · 2017Article
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Authors and funding
6 authors.
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Abstract
Training can improve the ability to discriminate between similar, confusable stimuli, including odors. One possibility of enhancing behaviorally expressed discrimination (i.e., sensory acuity) relies on differential associative learning, during which animals are forced to detect the differences between similar stimuli. Drosophila represents a key model organism for analyzing neuronal mechanisms underlying both odor processing and olfactory learning. However, the ability of flies to enhance fine discrimination between similar odors through differential associative learning has not been analyzed in detail. We performed associative conditioning experiments using chemically similar odorants that we show to evoke overlapping neuronal activity in the fly's antennal lobes and highly correlated activity in mushroom body lobes. We compared the animals' performance in discriminating between these odors after subjecting them to one of two types of training: either absolute conditioning, in which only one odor is reinforced, or differential conditioning, in which one odor is reinforced and a second odor is explicitly not reinforced. First, we show that differential conditioning decreases behavioral generalization of similar odorants in a choice situation. Second, we demonstrate that this learned enhancement in olfactory acuity relies on both conditioned excitation and conditioned inhibition. Third, inhibitory local interneurons in the antennal lobes are shown to be required for behavioral fine discrimination between the two similar odors. Fourth, differential, but not absolute, training causes decorrelation of odor representations in the mushroom body. In conclusion, differential training with similar odors ultimately induces a behaviorally expressed contrast enhancement between the two similar stimuli that facilitates fine discrimination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.