ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Bidirectional plasticity of Purkinje cells matches temporal features of learning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Classical conditioning of Purkinje cell responsesBiochemistry and biophysics reports · 2026Article
- Early insights into eyeblink conditioning using optically pumped magnetometer-based MEG.Frontiers in human neuroscience · 2025Article
- A computational passage-of-time model of the cerebellar Purkinje cell in eyeblink conditioning.Frontiers in computational neuroscience · 2023Article
- Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity.Communications biology · 2022Article
- NMDARs in granule cells contribute to parallel fiber-Purkinje cell synaptic plasticity and motor learning.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Bidirectional learning in upbound and downbound microzones of the cerebellum.Nature reviews. Neuroscience · 2021Review
- Brain-inspired classical conditioning model.iScience · 2021Article
- Targeting Sensory and Motor Integration for Recovery of Movement After CNS Injury.Frontiers in neuroscience · 2021Review
- A biochemical mechanism for time-encoding memory formation within individual synapses of Purkinje cells.PloS one · 2021Article
- A model for time interval learning in the Purkinje cell.PLoS computational biology · 2020Article
- Complex spike clusters and false-positive rejection in a cerebellar supervised learning rule.The Journal of physiology · 2019Article
- Reevaluating the ability of cerebellum in associative motor learning.Scientific reports · 2019Article
- Consensus paper: Decoding the Contributions of the Cerebellum as a Time Machine. From Neurons to Clinical Applications.Cerebellum (London, England) · 2019Article
- Depressed by Learning-Heterogeneity of the Plasticity Rules at Parallel Fiber Synapses onto Purkinje Cells.Cerebellum (London, England) · 2018Review
- Cerebellar learning using perturbations.eLife · 2018Article
- A Longer Interstimulus Interval Yields Better Learning in Adults and Young Adolescents.Frontiers in behavioral neuroscience · 2018Article
- Mechanisms underlying vestibulo-cerebellar motor learning in mice depend on movement direction.The Journal of physiology · 2017Article
- Learned response sequences in cerebellar Purkinje cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Are Purkinje Cell Pauses Drivers of Classically Conditioned Blink Responses?Cerebellum (London, England) · 2016Review
- Asymmetries in Cerebellar Plasticity and Motor Learning.Cerebellum (London, England) · 2016Review
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6 authors.
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Abstract
Many forms of learning require temporally ordered stimuli. In Pavlovian eyeblink conditioning, a conditioned stimulus (CS) must precede the unconditioned stimulus (US) by at least about 100 ms for learning to occur. Conditioned responses are learned and generated by the cerebellum. Recordings from the cerebellar cortex during conditioning have revealed CS-triggered pauses in the firing of Purkinje cells that likely drive the conditioned blinks. The predominant view of the learning mechanism in conditioning is that long-term depression (LTD) at parallel fiber (PF)-Purkinje cell synapses underlies the Purkinje cell pauses. This raises a serious conceptual challenge because LTD is most effectively induced at short CS-US intervals, which do not support acquisition of eyeblinks. To resolve this discrepancy, we recorded Purkinje cells during conditioning with short or long CS-US intervals. Decerebrated ferrets trained with CS-US intervals ≥150 ms reliably developed Purkinje cell pauses, but training with an interval of 50 ms unexpectedly induced increases in CS-evoked spiking. This bidirectional modulation of Purkinje cell activity offers a basis for the requirement of a minimum CS-US interval for conditioning, but we argue that it cannot be fully explained by LTD, even when previous in vitro studies of stimulus-timing-dependent LTD are taken into account.
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