ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Large-scale axonal reorganization of inhibitory neurons following retinal lesions.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- How perceptual learning rewires brain connectivity: lessons from the visual system in a top-down perspective.Frontiers in neural circuits · 2025Pooled it
- Multiple autism genes influence GABA neuron remodeling via distinct developmental trajectories.Genetics · 2025Article
- Multiple autism genes influence GABA neuron remodeling via distinct developmental trajectories.bioRxiv : the preprint server for biology · 2025Article
- Growth rules for the repair of Asynchronous Irregular neuronal networks after peripheral lesions.PLoS computational biology · 2021Article
- Functional Weight of Somatic and Cognitive Networks and Asymmetry of Compensatory Mechanisms: Collaboration or Divergency among Hemispheres after Cerebrovascular Accident?Life (Basel, Switzerland) · 2021Review
- Neuron class-specific responses govern adaptive myelin remodeling in the neocortex.Science (New York, N.Y.) · 2020Article
- Altered properties of brain white matter structural networks in patients with nasopharyngeal carcinoma after radiotherapy.Brain imaging and behavior · 2020Article
- Rapid topographic reorganization in adult human primary visual cortex (V1) during noninvasive and reversible deprivation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Stability in the Face of Change: Lifelong Experience-Dependent Plasticity in the Sensory Cortex.Frontiers in cellular neuroscience · 2020Article
- Preserved evoked conscious perception of phosphenes with direct stimulation of deafferented primary visual cortex.Epilepsy & behavior case reports · 2019Article
- Functionally specific optogenetic modulation in primate visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Axonal plasticity associated with perceptual learning in adult macaque primary visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- Homeostatic plasticity in human extrastriate cortex following a simulated peripheral scotoma.Experimental brain research · 2017Article
- Learning to see again: biological constraints on cortical plasticity and the implications for sight restoration technologies.Journal of neural engineering · 2017Review
- Article
- Primary visual cortical remapping in patients with inherited peripheral retinal degeneration.NeuroImage. Clinical · 2017Article
- Experience-Dependent Structural Plasticity in the Visual System.Annual review of vision science · 2016Review
- Homeostatic Plasticity of Subcellular Neuronal Structures: From Inputs to Outputs.Trends in neurosciences · 2016Review
- Physiological role for amyloid precursor protein in adult experience-dependent plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The functional properties of adult cortical neurons are subject to alterations in sensory experience. Retinal lesions lead to remapping of cortical topography in the region of primary visual cortex representing the lesioned part of the retina, the lesion projection zone (LPZ), with receptive fields shifting to the intact parts of the retina. Neurons within the LPZ receive strengthened input from the surrounding region by growth of the plexus of excitatory long-range horizontal connections. Here, by combining cell type-specific labeling with a genetically engineered recombinant adeno-associated virus and in vivo two-photon microscopy in adult macaques, we showed that the remapping was also associated with alterations in the axonal arbors of inhibitory neurons, which underwent a parallel process of pruning and growth. The axons of inhibitory neurons located within the LPZ extended across the LPZ border, suggesting a mechanism by which new excitatory input arising from the peri-LPZ is balanced by reciprocal inhibition arising from the LPZ.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.