Evidence map›Paper›PMID 24478337›Full record

ArticleGenetics2014

Heterochromatin position effects on circularized sex chromosomes cause filicidal embryonic lethality in Drosophila melanogaster.

Patrick M Ferree, Karina Gomez, Peter Rominger, Dagnie Howard, Hannah Kornfeld, Daniel A Barbash

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Patrick M FerreeW. M. Keck Science Department, Claremont McKenna, Pitzer, and Scripps Colleges, Claremont, California 91711.
Karina Gomez
Peter Rominger
Dagnie Howard
Hannah Kornfeld
Daniel A Barbash
Scripps College · USCornell University · US

Funding

Molecular Genetics of Drosophila Hybrid LethalityR01GM074737 · NIGMS · CORNELL UNIVERSITY ITHACA · PI BARBASH, DANIEL A · 2005 to 2022
$4.7M
NIGMS NIH HHS 2R01GM074737NIGMS NIH HHS R01 GM074737
6 · The paper itself

Abstract

Some circularized X-Y chromosomes in Drosophila melanogaster are mitotically unstable and induce early embryonic lethality, but the genetic basis is unknown. Our experiments suggest that a large region of X-linked satellite DNA causes anaphase bridges and lethality when placed into a new heterochromatic environment within certain circularized X-Y chromosomes. These results reveal that repetitive sequences can be incompatible with one another in cis. The lethal phenotype also bears a remarkable resemblance to a case of interspecific hybrid lethality.

Indexed as

AnaphaseAnimalsChromosomes, InsectDrosophila melanogasterFemaleGenes, InsectGenes, LethalHeterochromatinMaleRepetitive Sequences, Nucleic AcidRing ChromosomesSex ChromosomesHeterochromatin

Identifiers

PMID24478337
PMCPMC3982693
OpenAlexW2166450610

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.