Trial reportSocial cognitive and affective neuroscience2014
Early life stress modulates oxytocin effects on limbic system during acute psychosocial stress.
Open access · bronzeAbstract readPragmatic Clinical Trial
In one paragraph
Trial report in Social cognitive and affective neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
12.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Functional MRI Techniques Suggesting that the Stress System Interacts with Three Large Scale Core Brain Networks to Help Coordinate the Adaptive Response: A Systematic Review.Current neuropharmacology · 2024Pooled it
- The interaction of oxytocin and nicotine addiction on psychosocial stress: an fMRI study.Translational psychiatry · 2024Trial
- Preliminary data on oxytocin modulation of neural reactivity in women to emotional stimuli of children depending on childhood emotional neglect.Developmental psychobiology · 2023Trial
- Brain activation and subjective anxiety during an anticipatory anxiety task is related to clinical outcome during prazosin treatment for alcohol use disorder.NeuroImage. Clinical · 2020Trial
- Oxytocin effects on self-referential processing: behavioral and neuroimaging evidence.Social cognitive and affective neuroscience · 2017Trial
- Does oxytocin lead to emotional interference during a working memory paradigm?Psychopharmacology · 2017Trial
- Effects of intranasal oxytocin on amygdala reactivity to emotional faces in recently trauma-exposed individuals.Social cognitive and affective neuroscience · 2016Trial
- Amygdala-Hippocampal Connectivity Changes During Acute Psychosocial Stress: Joint Effect of Early Life Stress and Oxytocin.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- Early life stress modulates amygdala-prefrontal functional connectivity: implications for oxytocin effects.Human brain mapping · 2014Trial
- Methylome-Wide Association Studies of Physical Injury Stratified by Depression Status Assesses Exposure by Diagnosis Effects in Oxytocin Signaling and Synaptic Plasticity.Biological psychiatry global open science · 2026Article
- Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders.Cell & bioscience · 2023Review
- Maternal distress, DNA methylation, and fetal programing of stress physiology in Brazilian mother-infant pairs.Developmental psychobiology · 2023Article
- The Interaction Effect of Parental Rejection and Oxytocin Receptor Gene Polymorphism on Depression: A Cross-Cultural Study in Non-Clinical Samples.International journal of environmental research and public health · 2022Article
- Effect of Mindfulness Versus Loving-kindness Training on Leukocyte Gene Expression in Midlife Adults Raised in Low-Socioeconomic Status Households.Mindfulness · 2022Article
- Distinct stress-related medial prefrontal cortex activation in women with depression with and without childhood maltreatment.Depression and anxiety · 2022Article
- Effects of intranasal oxytocin on neural reward processing in children and adolescents with reactive attachment disorder: A randomized controlled trial.Frontiers in child and adolescent psychiatry · 2022Article
- Roles of Oxytocin in Stress Responses, Allostasis and Resilience.International journal of molecular sciences · 2021Review
- Love, fear, and the human-animal bond: On adversity and multispecies relationships.Comprehensive psychoneuroendocrinology · 2021Article
- Review of eating disorders and oxytocin receptor polymorphisms.Journal of eating disorders · 2021Review
- Early Trauma Is Associated with Poor Pharmacological Treatment Response in Patients with Panic Disorder.Psychiatry investigation · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 4 countries.
Simone GrimmCluster of Excellence 'Languages of Emotion', Freie Universitaet Berlin, 14195 Berlin, Germany, Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 14050 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universitaet Berlin, 14195 Berlin, Germany, Clinic for Affective Disorders and General Psychiatry, Psychiatric University Hospital Zurich, 8032 Zurich, Switzerland, Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China, Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec H4H 1R3, Canada, Montreal Neurological Institute, McGill University, Montreal, Quebec H4H 1R3, Canada, and University of Zurich, Institute of Psychology, Department of Psychology Clinical Psychology and Psychotherapy, 8050 Zurich, Switzerland Cluster of Excellence 'Languages of Emotion', Freie Universitaet Berlin, 14195 Berlin, Germany, Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 14050 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universitaet Berlin, 14195 Berlin, Germany, Clinic for Affective Disorders and General Psychiatry, Psychiatric University Hospital Zurich, 8032 Zurich, Switzerland, Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China, Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec H4H 1R3, Canada, Montreal Neurological Institute, McGill University, Montreal, Quebec H4H 1R3, Canada, and University of Zurich, Institute of Psychology, Department of Psychology Clinical Psychology and Psychotherapy, 8050 Zurich, Switzerland Cluster of Excellence 'Languages of Emotion', Freie Universitaet Berlin, 14195 Berlin, Germany, Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 14050 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universitaet Berlin, 14195 Ber
Karin PestkeCluster of Excellence 'Languages of Emotion', Freie Universitaet Berlin, 14195 Berlin, Germany, Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 14050 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universitaet Berlin, 14195 Berlin, Germany, Clinic for Affective Disorders and General Psychiatry, Psychiatric University Hospital Zurich, 8032 Zurich, Switzerland, Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China, Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec H4H 1R3, Canada, Montreal Neurological Institute, McGill University, Montreal, Quebec H4H 1R3, Canada, and University of Zurich, Institute of Psychology, Department of Psychology Clinical Psychology and Psychotherapy, 8050 Zurich, Switzerland Cluster of Excellence 'Languages of Emotion', Freie Universitaet Berlin, 14195 Berlin, Germany, Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 14050 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universitaet Berlin, 14195 Berlin, Germany, Clinic for Affective Disorders and General Psychiatry, Psychiatric University Hospital Zurich, 8032 Zurich, Switzerland, Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China, Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec H4H 1R3, Canada, Montreal Neurological Institute, McGill University, Montreal, Quebec H4H 1R3, Canada, and University of Zurich, Institute of Psychology, Department of Psychology Clinical Psychology and Psychotherapy, 8050 Zurich, Switzerland.
Melanie FeeserCluster of Excellence 'Languages of Emotion', Freie Universitaet Berlin, 14195 Berlin, Germany, Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 14050 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universitaet Berlin, 14195 Berlin, Germany, Clinic for Affective Disorders and General Psychiatry, Psychiatric University Hospital Zurich, 8032 Zurich, Switzerland, Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China, Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec H4H 1R3, Canada, Montreal Neurological Institute, McGill University, Montreal, Quebec H4H 1R3, Canada, and University of Zurich, Institute of Psychology, Department of Psychology Clinical Psychology and Psychotherapy, 8050 Zurich, Switzerland Cluster of Excellence 'Languages of Emotion', Freie Universitaet Berlin, 14195 Berlin, Germany, Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 14050 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universitaet Berlin, 14195 Berlin, Germany, Clinic for Affective Disorders and General Psychiatry, Psychiatric University Hospital Zurich, 8032 Zurich, Switzerland, Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China, Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec H4H 1R3, Canada, Montreal Neurological Institute, McGill University, Montreal, Quebec H4H 1R3, Canada, and University of Zurich, Institute of Psychology, Department of Psychology Clinical Psychology and Psychotherapy, 8050 Zurich, Switzerland.
Sabine AustCluster of Excellence 'Languages of Emotion', Freie Universitaet Berlin, 14195 Berlin, Germany, Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 14050 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universitaet Berlin, 14195 Berlin, Germany, Clinic for Affective Disorders and General Psychiatry, Psychiatric University Hospital Zurich, 8032 Zurich, Switzerland, Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China, Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec H4H 1R3, Canada, Montreal Neurological Institute, McGill University, Montreal, Quebec H4H 1R3, Canada, and University of Zurich, Institute of Psychology, Department of Psychology Clinical Psychology and Psychotherapy, 8050 Zurich, Switzerland Cluster of Excellence 'Languages of Emotion', Freie Universitaet Berlin, 14195 Berlin, Germany, Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 14050 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universitaet Berlin, 14195 Berlin, Germany, Clinic for Affective Disorders and General Psychiatry, Psychiatric University Hospital Zurich, 8032 Zurich, Switzerland, Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China, Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec H4H 1R3, Canada, Montreal Neurological Institute, McGill University, Montreal, Quebec H4H 1R3, Canada, and University of Zurich, Institute of Psychology, Department of Psychology Clinical Psychology and Psychotherapy, 8050 Zurich, Switzerland Cluster of Excellence 'Languages of Emotion', Freie Universitaet Berlin, 14195 Berlin, Germany, Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 14050 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universitaet Berlin, 14195 Ber
Anne WeigandCluster of Excellence 'Languages of Emotion', Freie Universitaet Berlin, 14195 Berlin, Germany, Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 14050 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universitaet Berlin, 14195 Berlin, Germany, Clinic for Affective Disorders and General Psychiatry, Psychiatric University Hospital Zurich, 8032 Zurich, Switzerland, Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China, Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec H4H 1R3, Canada, Montreal Neurological Institute, McGill University, Montreal, Quebec H4H 1R3, Canada, and University of Zurich, Institute of Psychology, Department of Psychology Clinical Psychology and Psychotherapy, 8050 Zurich, Switzerland Cluster of Excellence 'Languages of Emotion', Freie Universitaet Berlin, 14195 Berlin, Germany, Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 14050 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universitaet Berlin, 14195 Berlin, Germany, Clinic for Affective Disorders and General Psychiatry, Psychiatric University Hospital Zurich, 8032 Zurich, Switzerland, Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China, Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec H4H 1R3, Canada, Montreal Neurological Institute, McGill University, Montreal, Quebec H4H 1R3, Canada, and University of Zurich, Institute of Psychology, Department of Psychology Clinical Psychology and Psychotherapy, 8050 Zurich, Switzerland Cluster of Excellence 'Languages of Emotion', Freie Universitaet Berlin, 14195 Berlin, Germany, Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 14050 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universitaet Berlin, 14195 Ber
Jue WangCluster of Excellence 'Languages of Emotion', Freie Universitaet Berlin, 14195 Berlin, Germany, Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 14050 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universitaet Berlin, 14195 Berlin, Germany, Clinic for Affective Disorders and General Psychiatry, Psychiatric University Hospital Zurich, 8032 Zurich, Switzerland, Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China, Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec H4H 1R3, Canada, Montreal Neurological Institute, McGill University, Montreal, Quebec H4H 1R3, Canada, and University of Zurich, Institute of Psychology, Department of Psychology Clinical Psychology and Psychotherapy, 8050 Zurich, Switzerland.
Katja WingenfeldCluster of Excellence 'Languages of Emotion', Freie Universitaet Berlin, 14195 Berlin, Germany, Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 14050 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universitaet Berlin, 14195 Berlin, Germany, Clinic for Affective Disorders and General Psychiatry, Psychiatric University Hospital Zurich, 8032 Zurich, Switzerland, Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China, Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec H4H 1R3, Canada, Montreal Neurological Institute, McGill University, Montreal, Quebec H4H 1R3, Canada, and University of Zurich, Institute of Psychology, Department of Psychology Clinical Psychology and Psychotherapy, 8050 Zurich, Switzerland.
Jens C PruessnerCluster of Excellence 'Languages of Emotion', Freie Universitaet Berlin, 14195 Berlin, Germany, Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 14050 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universitaet Berlin, 14195 Berlin, Germany, Clinic for Affective Disorders and General Psychiatry, Psychiatric University Hospital Zurich, 8032 Zurich, Switzerland, Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China, Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec H4H 1R3, Canada, Montreal Neurological Institute, McGill University, Montreal, Quebec H4H 1R3, Canada, and University of Zurich, Institute of Psychology, Department of Psychology Clinical Psychology and Psychotherapy, 8050 Zurich, Switzerland Cluster of Excellence 'Languages of Emotion', Freie Universitaet Berlin, 14195 Berlin, Germany, Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 14050 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universitaet Berlin, 14195 Berlin, Germany, Clinic for Affective Disorders and General Psychiatry, Psychiatric University Hospital Zurich, 8032 Zurich, Switzerland, Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China, Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec H4H 1R3, Canada, Montreal Neurological Institute, McGill University, Montreal, Quebec H4H 1R3, Canada, and University of Zurich, Institute of Psychology, Department of Psychology Clinical Psychology and Psychotherapy, 8050 Zurich, Switzerland.
Roberto La MarcaCluster of Excellence 'Languages of Emotion', Freie Universitaet Berlin, 14195 Berlin, Germany, Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 14050 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universitaet Berlin, 14195 Berlin, Germany, Clinic for Affective Disorders and General Psychiatry, Psychiatric University Hospital Zurich, 8032 Zurich, Switzerland, Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China, Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec H4H 1R3, Canada, Montreal Neurological Institute, McGill University, Montreal, Quebec H4H 1R3, Canada, and University of Zurich, Institute of Psychology, Department of Psychology Clinical Psychology and Psychotherapy, 8050 Zurich, Switzerland.
Heinz BökerCluster of Excellence 'Languages of Emotion', Freie Universitaet Berlin, 14195 Berlin, Germany, Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 14050 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universitaet Berlin, 14195 Berlin, Germany, Clinic for Affective Disorders and General Psychiatry, Psychiatric University Hospital Zurich, 8032 Zurich, Switzerland, Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China, Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec H4H 1R3, Canada, Montreal Neurological Institute, McGill University, Montreal, Quebec H4H 1R3, Canada, and University of Zurich, Institute of Psychology, Department of Psychology Clinical Psychology and Psychotherapy, 8050 Zurich, Switzerland.
Malek BajboujCluster of Excellence 'Languages of Emotion', Freie Universitaet Berlin, 14195 Berlin, Germany, Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 14050 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universitaet Berlin, 14195 Berlin, Germany, Clinic for Affective Disorders and General Psychiatry, Psychiatric University Hospital Zurich, 8032 Zurich, Switzerland, Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China, Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec H4H 1R3, Canada, Montreal Neurological Institute, McGill University, Montreal, Quebec H4H 1R3, Canada, and University of Zurich, Institute of Psychology, Department of Psychology Clinical Psychology and Psychotherapy, 8050 Zurich, Switzerland Cluster of Excellence 'Languages of Emotion', Freie Universitaet Berlin, 14195 Berlin, Germany, Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 14050 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universitaet Berlin, 14195 Berlin, Germany, Clinic for Affective Disorders and General Psychiatry, Psychiatric University Hospital Zurich, 8032 Zurich, Switzerland, Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China, Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec H4H 1R3, Canada, Montreal Neurological Institute, McGill University, Montreal, Quebec H4H 1R3, Canada, and University of Zurich, Institute of Psychology, Department of Psychology Clinical Psychology and Psychotherapy, 8050 Zurich, Switzerland Cluster of Excellence 'Languages of Emotion', Freie Universitaet Berlin, 14195 Berlin, Germany, Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, 14050 Berlin, Germany, Dahlem Institute for Neuroimaging of Emotion, Freie Universitaet Berlin, 14195 Ber
Freie Universität Berlin · DECharité - Universitätsmedizin Berlin · DEDouglas Mental Health University Institute · CAHangzhou Normal University · CNUniversitäre Psychiatrische Dienste Bern · CHUniversity of Zurich · CH
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early life stress (ELS) is associated with altered stress responsivity, structural and functional brain changes and an increased risk for the development of psychopathological conditions in later life. Due to its behavioral and physiological effects, the neuropeptide oxytocin (OXT) is a useful tool to investigate stress responsivity, even though the neurobiological underpinnings of its effects are still unknown. Here we investigate the effects of OXT on cortisol stress response and neural activity during psychosocial stress. Using functional magnetic resonance imaging in healthy subjects with and without a history of ELS, we found attenuated hormonal reactivity and significantly reduced limbic deactivation after OXT administration in subjects without a history of ELS. Subjects who experienced ELS showed both blunted stress reactivity and limbic deactivation during stress. Furthermore, in these subjects OXT had opposite effects with increased hormonal reactivity and increased limbic deactivation. Our results might implicate that reduced limbic deactivation and hypothalamic-pituitary-adrenal axis responsivity during psychosocial stress are markers for biological resilience after ELS. Effects of OXT in subjects with a history of maltreatment could therefore be considered detrimental and suggest careful consideration of OXT administration in such individuals.
Indexed as
AdultAnalysis of VarianceChildChild AbuseDouble-Blind MethodFemaleHumansHydrocortisoneImage Processing, Computer-AssistedLimbic SystemMagnetic Resonance ImagingMaleOxygenOxytocinPsychiatric Status Rating ScalesPsychological TestsHydrocortisoneOxygenOxytocinearly life stressoxytocinstress
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