Evidence map›Paper›PMID 24478317›Full record

ArticleThe Journal of biological chemistry2014

Platelet-activating factor contributes to Bacillus anthracis lethal toxin-associated damage.

Johanna Rivera, Rani S Sellers, Wangyong Zeng, Nico van Rooijen, Arturo Casadevall, David L Goldman

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Johanna RiveraDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461.
Rani S SellersDepartment of Medicine (Division of Infectious Diseases), Albert Einstein College of Medicine, Bronx, New York 10461.
Wangyong ZengDepartment of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461.
Nico van RooijenDepartment of Molecular Cell Biology, Vrije Universiteit, 1081 BT Amsterdam, The Netherlands.
Arturo CasadevallDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461; Department of Medicine (Division of Infectious Diseases), Albert Einstein College of Medicine, Bronx, New York 10461.
David L GoldmanDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461; Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461. Electronic address: david.goldman@einstein.yu.edu.
Albert Einstein College of Medicine · USVrije Universiteit Amsterdam · NL

Funding

Viral Pathogenesis and TherapeuticsU54AI057158 · NIAID · WADSWORTH CENTER · PI LIPKIN, W. IAN · 2003 to 2014
$100.8M
Synergy of Host Defense Mechanisms in the LungR01HL059842 · NHLBI · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1997 to 2023
$7.4M
Biology of Fungal MelaninR01AI052733 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 2003 to 2019
$6.6M
PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONSR01AI033774 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1994 to 2014
$5.6M
Molecular Characterization of C. neoformans AntibodiesR37AI033142 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CASADEVALL, ARTURO · 2007 to 2016
$3.9M
MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIESR01AI033142 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1994 to 2006
$1.7M
NHLBI NIH HHS R01 HL059842NIAID NIH HHS R01 AI033142NIAID NIH HHS R01 AI033774NIAID NIH HHS R01 AI052733NIAID NIH HHS R37 AI033142NIAID NIH HHS U54 AI057158
6 · The paper itself

Abstract

The lethal toxin (LeTx) of Bacillus anthracis plays a central role in the pathogenesis of anthrax-associated shock. Platelet-activating factor (PAF) is a potent lipid mediator that has been implicated in endotoxin-associated shock. In this study, we examined the contribution of PAF to the manifestations of lethal toxin challenge in WT mice. LeTx challenge resulted in transient increase in serum PAF levels and a concurrent decrease in PAF acetylhydrolase activity. Inhibition of PAF activity using PAF antagonists or toxin challenge of PAF receptor negative mice reversed or ameliorated many of the pathologic features of LeTx-induced damage, including changes in vascular permeability, hepatic necrosis, and cellular apoptosis. In contrast, PAF inhibition had minimal effects on cytokine levels. Findings from these studies support the continued study of PAF antagonists as potential adjunctive agents in the treatment of anthrax-associated shock.

Indexed as

AnimalsAnthraxAntigens, BacterialBacillus anthracisBacterial ToxinsChemokinesCytokinesFemaleLungMiceMice, Inbred BALB CMice, Mutant StrainsPlatelet Activating FactorSpleenanthrax toxinAntigens, BacterialBacterial ToxinsChemokinesCytokinesPlatelet Activating FactorAnthrax ToxinBacterial PathogenesisCytokineLipidsMacrophagesPlatelet-activating Factor

Identifiers

PMID24478317
PMCPMC3945373
OpenAlexW2097069996

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.