ArticleProceedings. Biological sciences2014
Heritable variation in host tolerance and resistance inferred from a wild host-parasite system.
Article in Proceedings. Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Coevolution of host resistance and pathogen exploitation in a propagule-mediated infection model.PLoS computational biology · 2026Article
- Dissecting transmission to understand parasite evolution.PLoS pathogens · 2025Review
- A Palearctic view of a bat fungal disease.Conservation biology : the journal of the Society for Conservation Biology · 2025Review
- Shifted levels of sleep and activity during the night as mechanisms underlying ectoparasite resistance.Npj biological timing and sleep · 2025Article
- Host Resistance and Behavior Determine Invasion Dynamics of a Detrimental Aquatic Disease.Ecology and evolution · 2024Article
- Susceptibility to a sexually transmitted disease in a wild koala population shows heritable genetic variance but no inbreeding depression.Molecular ecology · 2022Article
- Predictors of individual performance and evolutionary potential of life-history traits in a hematophagous ectoparasite.Evolution; international journal of organic evolution · 2022Article
- Between-population differences in constitutive and infection-induced gene expression in threespine stickleback.Molecular ecology · 2021Article
- Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm.eLife · 2021Review
- Ineffective humoral anti-tick IgY-response in birds: reaction against pathogen constituents?Open research Europe · 2021Article
- Coupling between tolerance and resistance for two relatedEcology and evolution · 2020Article
- Interactions with ectoparasitic mites induce host metabolic and immune responses in flies at the expense of reproduction-associated factors.Parasitology · 2020Article
- The evolution of resistance and tolerance as cancer defences.Parasitology · 2020Article
- Annual environmental variation influences host tolerance to parasites.Proceedings. Biological sciences · 2019Article
- Disentangling Genetic Variation for Resistance and Endurance to Scuticociliatosis in Turbot Using Pedigree and Genomic Information.Frontiers in genetics · 2019Article
- The Missing Response to Selection in the Wild.Trends in ecology & evolution · 2018Article
- The effect of parasite infection on the recombination rate of the mosquito Aedes aegypti.PloS one · 2018Article
- Vertebrate defense against parasites: Interactions between avoidance, resistance, and tolerance.Ecology and evolution · 2017Article
- Effects of protein malnutrition on tolerance to helminth infection.Biology letters · 2016Article
- Health trajectories reveal the dynamic contributions of host genetic resistance and tolerance to infection outcome.Proceedings. Biological sciences · 2015Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hosts have evolved two distinct defence strategies against parasites: resistance (which prevents infection or limit parasite growth) and tolerance (which alleviates the fitness consequences of infection). However, heritable variation in resistance and tolerance and the genetic correlation between these two traits have rarely been characterized in wild host populations. Here, we estimate these parameters for both traits in Leuciscus burdigalensis, a freshwater fish parasitized by Tracheliastes polycolpus. We used a genetic database to construct a full-sib pedigree in a wild L. burdigalensis population. We then used univariate animal models to estimate inclusive heritability (i.e. all forms of genetic and non-genetic inheritance) in resistance and tolerance. Finally, we assessed the genetic correlation between these two traits using a bivariate animal model. We found significant heritability for resistance (H = 17.6%; 95% CI: 7.2-32.2%) and tolerance (H = 18.8%; 95% CI: 4.4-36.1%), whereas we found no evidence for the existence of a genetic correlation between these traits. Furthermore, we confirm that resistance and tolerance are strongly affected by environmental effects. Our results demonstrate that (i) heritable variation exists for parasite resistance and tolerance in wild host populations, and (ii) these traits can evolve independently in populations.
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