ReviewGenesis (New York, N.Y. : 2000)2014
Asymmetric neural development in the Caenorhabditis elegans olfactory system.
Review in Genesis (New York, N.Y. : 2000), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- A JNK-interacting protein 1 acts across the midline to mediate synaptic localization of the SARM1 calcium-signaling scaffold protein for asymmetric neuronal fate choice.bioRxiv : the preprint server for biology · 2026Article
- An apical junction protein antagonizes mechanosensitive calcium signaling to establish stochastic choices of olfactory neuron subtypes.bioRxiv : the preprint server for biology · 2026Article
- Kinesin-1 trans-synaptically regulates synaptic localization of SARM1 for asymmetric neuron diversification.bioRxiv : the preprint server for biology · 2026Article
- The vab-1/Eph receptor and ephrins efn-1 and efn-4 are required for C. elegans chemosensory and thermosensory circuit assembly and function.BMC neuroscience · 2025Article
- The anticonvulsant and mood-stabilizing drug valproic acid attractsbioRxiv : the preprint server for biology · 2025Article
- A gene expression atlas of a juvenile nervous system.bioRxiv : the preprint server for biology · 2025Article
- Free long-chain fatty acids trigger early postembryonic development in starved Caenorhabditis elegans by suppressing mTORC1.PLoS biology · 2024Article
- Article
- Physical presence of chemical synapses is necessary for turning behavior of anterograde synaptic vesicles at the branch point of PLM neurons inmicroPublication biology · 2024Article
- Embodied cognitive morphogenesis as a route to intelligent systems.Interface focus · 2023Article
- Left-right asymmetry in oxidative stress sensing neurons inmicroPublication biology · 2022Article
- Article
- Homeobox genes and the specification of neuronal identity.Nature reviews. Neuroscience · 2021Review
- Circumventing neural damage in a C. elegans chemosensory circuit using genetically engineered synapses.Cell systems · 2021Article
- Signaling by AWC Olfactory Neurons Is Necessary forGenetics · 2020Article
- Raising the Connectome: The Emergence of Neuronal Activity and Behavior inFrontiers in cellular neuroscience · 2020Article
- A universal transportin protein drives stochastic choice of olfactory neurons via specific nuclear import of aProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Asymmetric development of the nervous system.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
- An atlas of Caenorhabditis elegans chemoreceptor expression.PLoS biology · 2018Article
- Mechanisms controlling diversification of olfactory sensory neuron classes.Cellular and molecular life sciences : CMLS · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Asymmetries in the nervous system have been observed throughout the animal kingdom. Deviations of brain asymmetries are associated with a variety of neurodevelopmental disorders; however, there has been limited progress in determining how normal asymmetry is established in vertebrates. In the Caenorhabditis elegans chemosensory system, two pairs of morphologically symmetrical neurons exhibit molecular and functional asymmetries. This review focuses on the development of antisymmetry of the pair of amphid wing "C" (AWC) olfactory neurons, from transcriptional regulation of general cell identity, establishment of asymmetry through neural network formation and calcium signaling, to the maintenance of asymmetry throughout the life of the animal. Many of the factors that are involved in AWC development have homologs in vertebrates, which may potentially function in the development of vertebrate brain asymmetry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.