ArticleJournal of clinical laboratory analysis2014
Role of VEGF-C gene polymorphisms in susceptibility to hepatocellular carcinoma and its pathological development.
Article in Journal of clinical laboratory analysis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- From Pathophysiology to Practice: Evolving Pharmacological Therapies, Clinical Complications, and Pharmacogenetic Considerations in Portal Hypertension.Metabolites · 2025Review
- The Relationship between VEGFC Gene Polymorphisms and Autoimmune Thyroiditis.BioMed research international · 2022Article
- Association study between the polymorphisms of angiogenesis-related genes and cervical cancer susceptibility in Chinese Uygur population.Molecular genetics & genomic medicine · 2019Article
- KDR (VEGFR2) Genetic Variants and Serum Levels in Patients with Rheumatoid Arthritis.Biomolecules · 2019Article
- Association of intercellular adhesion molecule-1 single nucleotide polymorphisms with hepatocellular carcinoma susceptibility and clinicopathologic development.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- CD105 promotes hepatocarcinoma cell invasion and metastasis through VEGF.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Fibroblast growth factor receptor 4 polymorphism is associated with liver cirrhosis in hepatocarcinoma.PloS one · 2015Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVascular endothelial growth factor C (VEGF-C), an angiogenic/lymphangiogenic factor with high expression levels in tumor tissues, plays important roles in the development of several malignancies including hepatocellular carcinoma (HCC). The purpose of this study was to examine whether VEGF-C gene polymorphisms are associated with susceptibility to HCC and its clinicopathological development.
methodsGenetic polymorphisms of VEGF-C of 135 patients with HCC and 520 noncancer controls were analyzed by a real-time polymerase chain reaction (PCR).
resultsWe found that a significantly (P = 0.021) higher risk for HCC was shown in individuals with the VEGF-C rs1485766 A/A genotype compared to those with wild-type homozygotes; a high frequency of an advanced stage and a low frequency of being positive for cirrhosis were respectively shown in HCC patients with the VEGF-C rs7664413 CT/TT and rs3775194 GC/CC genotypes. Moreover, we found that the GGACA, GACTG, CGATG, and GGCTG haplotypes of five VEGF-C single-nucleotide polymorphisms (SNPs) combined were also related to the risk of HCC.
conclusionsOur results suggest that the VEGF-C rs1485766 SNP and either of five haplotypes combined might contribute to a prediction of susceptibility to HCC. The genetic polymorphism of VEGF-C rs7664413 might be a predictive factor for advanced-stage HCC.
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