ArticlePediatric nephrology (Berlin, Germany)2014
Fetal renin-angiotensin-system blockade syndrome: renal lesions.
Article in Pediatric nephrology (Berlin, Germany), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adverse pregnancy outcomes associated with first-trimester exposure to angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers: A systematic review and meta-analysis.Pharmacology research & perspectives · 2020Pooled it
- Postnatal and long-term outcomes after in utero exposure to RAAS inhibitors: cohort study based on German claims data.Pediatric nephrology (Berlin, Germany) · 2026Article
- Rapid Normalization of Amniotic Fluid Index Following Discontinuation of Olmesartan: A Case Report.AJP reports · 2026Article
- Gestational age and fetal hypothyroidism Alter the porcine thyroid and local hepatic and renal renin-angiotensin systems.Physiological reports · 2025Article
- Neonatal Acute Kidney Injury due to Maternal Olmesartan Intake: Authors' Reply.Indian journal of pediatrics · 2024Article
- Patterns of differentiation of renin lineage cells during nephrogenesis.American journal of physiology. Renal physiology · 2021Article
- A Premature Baby with Severe Oligohydramnios and Hypotension: a Case Report of Renal Tubular Dysgenesis.Journal of Korean medical science · 2020Article
- Prenatal hypocalvaria after prolonged intrauterine exposure to angiotensin II receptor antagonists.Journal of the renin-angiotensin-aldosterone system : JRAASArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFetuses exposed to angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists during the second and/or third trimesters of gestation are at high risk of developing severe complications. They consist in fetal hypotension, and anuria/oligohydramnios leading to Potter sequence, frequently associated with hypocalvaria. Most fetuses die during the pre- or postnatal period, whereas others recover normal or subnormal renal function. However, the secondary occurrence of renal failure or hypertension has been reported in children after apparent complete recovery.
methodsIn this context, we analyzed renal lesions in 14 fetus/neonates who died soon after exposure to renin-angiotensin-system (RAS) blockers. Our objective was to determine the causes for the persistence or the secondary occurrence of renal complications reported in some of the survivors.
resultsAs previously described, renal tubular dysgenesis is usually observed. Additional lesions, such as thickening of the muscular wall of arterioles and interlobular arteries, glomerular cysts, and interstitial fibrosis, develop early during fetal life.
conclusionWe suggest that renal lesions that develop before birth may persist after withdrawal of the causative drugs and normalization of blood and renal perfusion pressure. Their persistence could explain the severe long-term outcome of some of these patients. Long-term study of children exposed to RAS blockers during fetal life is strongly recommended.
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