ArticleMolecular imaging and biology2014
Development of single vial kits for preparation of (68)Ga-labelled peptides for PET imaging of neuroendocrine tumours.
Article in Molecular imaging and biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- ScalableWorld journal of nuclear medicine · 2026Article
- Cold Kit Labeling: The Future ofFrontiers in medicine · 2022Review
- Towards Facile Radiolabeling and Preparation of Gallium-68-/Bismuth-213-DOTA-[ThiPharmaceutics · 2021Article
- Optimization of a Labeling and Kit Preparation Method for Ga-68 Labeled DOTATATE, Using Cation Exchange Resin Purified Ga-68 Eluates Obtained from a Tin DioxideMolecular imaging and biology · 2018Article
- Development and Evaluation of User-Friendly Single Vial DOTA-Peptide Kit Formulations, Specifically Designed for Radiolabelling withMolecular imaging and biology · 2017Article
- Evaluation of a Flexible NOTA-RGD Kit Solution Using Gallium-68 from DifferentMolecular imaging and biology · 2017Article
- Radiolabeling and Preliminary Evaluation of Ga-68 Labeled NODAGA-Ubiquicidin Fragments for Prospective Infection Imaging.Molecular imaging and biology · 2017Article
- Development of a Single Vial Kit Solution for Radiolabeling of 68Ga-DKFZ-PSMA-11 and Its Performance in Prostate Cancer Patients.Molecules (Basel, Switzerland) · 2015Article
- Drug delivery systems, CNS protection, and the blood brain barrier.BioMed research international · 2014Review
- Initial Clinical Experience withWorld journal of nuclear medicineArticle
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeThe present work was aimed at the formulation and evaluation of freeze-dried kits of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-peptides for the preparation of (68)Ga-labelled peptides for PET imaging of neuroendocrine tumours. The (68)GaCl3 was obtained from the locally produced nanoceria-PAN, composite-sorbent-based (68)Ge/(68)Ga generator. PROCEDURES: Single vial kits of somatostatin analogues DOTA-[Tyr(3)]-octreotide (DOTA-TOC), DOTA-[NaI(3)]-octreotide (DOTA-NOC) and DOTA-Tyr(3)-Thre(8)-octreotide (DOTA-TATE) were formulated. Optimization of radiolabelling with (68)Ga from the in-house generator, characterization, long term evaluation of stability of kits and bioevaluation studies in animals was carried out.
resultsDOTA-TOC, DOTA-NOC and DOTA-TATE kits could be successfully formulated. Consistently high radiochemical yields (>95 %) were obtained on radiolabelling with (68)Ga. The radiolabelled peptides exhibited excellent in vitro stability. Biodistribution studies in normal non-tumour bearing Swiss mice revealed fast clearance of activity via renal route as reported for the respective peptides.
conclusionAvailability of ready to use DOTA-peptide kits in conjunction with (68)Ge/(68)Ga generators would pave way for the establishment of (68)Ga radiopharmacy, a long-felt need of the nuclear medicine community.
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