ArticleInternational journal of colorectal disease2014
Does anastomotic leakage impair functional results and quality of life after laparoscopic sphincter-saving total mesorectal excision for rectal cancer? A case-matched study.
Article in International journal of colorectal disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Association between anastomotic leak after rectal resection and bowel dysfunction, a systematic review, meta-analysis and meta-regression.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Pooled it
- Impact of Anastomotic Leakage After Colorectal Cancer Surgery on Quality of Life: A Systematic Review.Diseases of the colon and rectum · 2025Pooled it
- Endoscopic Treatment Options for Gastrointestinal Leaks.Visceral medicine · 2022Pooled it
- Early anastomotic complications in colorectal surgery: a systematic review of techniques for endoscopic salvage.Surgical endoscopy · 2019Pooled it
- [Evidence of indocyanine green fluorescence in robotically assisted colorectal surgery : What is the status?]Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021Trial
- Total mesorectal excision with or without preoperative chemoradiotherapy for resectable mid/low rectal cancer: a long-term analysis of a prospective, single-center, randomized trial.Cancer communications (London, England) · 2018Trial
- Anorectal Function and Quality of Life in Patients With Early Stage Rectal Cancer Treated With Chemoradiation and Local Excision.Diseases of the colon and rectum · 2017Trial
- Impact of timing of ileostomy reversal and anastomotic leakage on bowel function and health-related quality of life following rectal cancer surgery: a cross-sectional study.Surgical endoscopy · 2026Article
- Patient-Reported Outcomes and Surgical Results of Hand-Sewn Versus Stapled Anastomosis for Lower Rectal Cancer Located 4-5 cm From the Anal Verge: A Subanalysis of the Ultimate Study.Annals of gastroenterological surgery · 2025Article
- Impact of anastomotic leakage and radiotherapy on long-term quality of life after sphincter-saving rectal resections.Langenbeck's archives of surgery · 2025Article
- Timing and morbidity of loop ileostomy closure after rectal cancer resection: a prospective observational multicentre snapshot study from Multidisciplinary Italian Study group for STOmas (MISSTO).International journal of colorectal disease · 2025Observational
- Outcomes of loop ileostomy after rectal resection for cancer: A prospective observational multicenter snapshot study from Multidisciplinary Italian Study group for STOmas (MISSTO).Techniques in coloproctology · 2024Observational
- Beyond survival: a comprehensive review of quality of life in rectal cancer patients.Annals of coloproctology · 2024Review
- Blood perfusion assessment by near-infrared fluorescence angiography of epiploic appendages in prevention of anastomotic leakage after laparoscopic intersphincteric resection for ultra-low rectal cancer: a case-matched study.Surgical endoscopy · 2024Article
- Risk factors for anastomotic leakage after low anterior resection for obese patients with rectal cancer.Surgery today · 2024Article
- Minor impact of anastomotic leakage in anterior resection for rectal cancer on long-term male urinary and sexual function.International journal of colorectal disease · 2024Article
- Role and Morbidity of Protective Ileostomy after Anterior Resection for Rectal Cancer: One Centre Experience and Review of Literature.Journal of clinical medicine · 2023Article
- Outcomes following anastomotic leak from rectal resections, including bowel function and quality of life.Annals of coloproctology · 2023Article
- Does stoma modify compliance with enhanced recovery after surgery programs? Results of a cohort study.International journal of colorectal disease · 2023Article
- Impact of near-infrared fluorescence imaging with indocyanine green on structural sequelae of anastomotic leakage after laparoscopic intersphincteric resection of malignant rectal tumors.Techniques in coloproctology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAnastomotic leakage (AL) after total mesorectal excision (TME) for rectal cancer is suspected to alter function. However, very few reports have been devoted to this problem. The aim of this study was to assess the influence of AL on function and quality of life (QoL) after laparoscopic TME for cancer.
methodsA total of 170 patients who underwent laparoscopic TME and sphincter-saving surgery for mid and low rectal cancer were included (67 % after neoadjuvant chemoradiotherapy). Twenty-one patients with AL were assessed for function and QoL (Short Form 36 (SF-36), Fecal Incontinence Quality of Life (FIQL), CR-29, and Wexner's score) at the most recent follow-up. These patients were matched to 42 patients without AL according to sex, body mass index, ypTNM, radiotherapy, and type of anastomosis.
resultsAfter a median follow-up of 30 months, AL significantly impaired physical activity (SF-36) (p = 0.004), self-respect (FIQL) (p = 0.029), wear pad's score (Wexner's score) (p = 0.043), and blood and mucus in stool score (CR-29) (p = 0.001). Overall Wexner's score did not show any significant difference in the two groups, 8.9 in AL patients vs. 11.6 in patients without AL (p = 0.1).
conclusionAL significantly impairs both functional results and quality of life after laparoscopic sphincter-saving TME for rectal cancer. However, the observed difference was only limited, leading to similar outcomes on most of the tested scores. Patients with AL should be warned that if they initially experience severely impaired results, outcomes tend with time to become similar to those observed in noncomplicated patients.
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