ArticleExperimental brain research2014
Consistent interindividual increases or decreases in muscle sympathetic nerve activity during experimental muscle pain.
Article in Experimental brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Concussion and the autonomic nervous system: An introduction to the field and the results of a systematic review.NeuroRehabilitation · 2018Pooled it
- Low-dose morphine reduces pain perception and blood pressure, but not muscle sympathetic outflow, responses during the cold pressor test.American journal of physiology. Heart and circulatory physiology · 2022Trial
- Low-dose fentanyl reduces pain perception, muscle sympathetic nerve activity responses, and blood pressure responses during the cold pressor test.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Trial
- Sex differences in the relationship between pain and autonomic outflow during a cold pressor test.Biology of sex differences · 2025Article
- Relationship between muscle sympathetic nerve activity and rapid increases in circulating leukocytes during experimental muscle pain.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Article
- The effects of audiovisual distraction on the muscle sympathetic responses to experimental muscle pain.Experimental brain research · 2018Article
- Muscle sympathetic nerve activity-coupled changes in brain activity during sustained muscle pain.Brain and behavior · 2018Article
- Central circuitry responsible for the divergent sympathetic responses to tonic muscle pain in humans.Human brain mapping · 2017Article
- Sympathetic Responses to Noxious Stimulation of Muscle and Skin.Frontiers in neurology · 2016Review
- Inter-Individual Responses to Experimental Muscle Pain: Baseline Physiological Parameters Do Not Determine Whether Muscle Sympathetic Nerve Activity Increases or Decreases During Pain.Frontiers in neuroscience · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We recently showed that long-lasting muscle pain, induced by intramuscular infusion of hypertonic saline, evoked two patterns of cardiovascular responses across subjects: one group showed parallel increases in muscle sympathetic nerve activity (MSNA), blood pressure, and heart rate, while the other group showed parallel decreases. Given that MSNA is consistent day to day, we tested the hypothesis that individuals who show increases in MSNA during experimental muscle pain will show consistent responses over time. MSNA was recorded from the peroneal nerve, together with blood pressure and heart rate, during an intramuscular infusion of hypertonic saline causing pain for an hour in 15 subjects on two occasions, 2-27 weeks apart. Pain intensity ratings were not significantly different between the first (5.8 ± 0.4/10) and second (6.1 ± 0.2) recording sessions. While four subjects showed significant decreases in the first session (46.6 ± 9.2% of baseline) and significant increases in the second (159.6 ± 8.9%), in 11 subjects, there was consistency in the changes in MSNA over time: either a sustained decrease (55.6 ± 6.8%, n = 6) or a sustained increase (143.5 ± 6.1%, n = 5) occurred in both recording sessions. There were no differences in pain ratings between sessions for any subjects. We conclude that the changes in MSNA during long-lasting muscle pain are consistent over time in the majority of individuals, reflecting the importance of studying interindividual differences in physiology.
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