ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2014
Supraoptic oxytocin and vasopressin neurons function as glucose and metabolic sensors.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 57 citations in OpenAlex.
- Peripheral oxytocin administration decreases the food intake and compulsive-like behavior in male rats in an animal model of binge-type eating.Psychopharmacology · 2026Article
- Hypothalamic malate dehydrogenase 2 modulates systemic glucose metabolism through oxytocin-mediated thermogenesis.Cell reports. Medicine · 2026Article
- Molecular Interaction Between Vasopressin and Insulin in Regulation of Metabolism: Impact on Cardiovascular and Metabolic Diseases.International journal of molecular sciences · 2024Review
- Arginine vasopressin in mood disorders: A potential biomarker of disease pathology and a target for pharmacologic intervention.Psychiatry and clinical neurosciences · 2024Review
- Protein Extract of a Probiotic Strain ofInternational journal of molecular sciences · 2023Article
- Measuring oxytocin release in response to gavage: Computational modelling and assay validation.Journal of neuroendocrinology · 2023Article
- A melanopsin ganglion cell subtype forms a dorsal retinal mosaic projecting to the supraoptic nucleus.Nature communications · 2023Article
- Oxytocin as a potential pharmacological tool to combat obesity.Journal of neuroendocrinology · 2022Review
- Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management.Journal of hematology & oncology · 2022Review
- The ventromedial hypothalamic nucleus: watchdog of whole-body glucose homeostasis.Cell & bioscience · 2022Review
- The physiological control of eating: signals, neurons, and networks.Physiological reviews · 2022 · on this mapArticle
- Missing pieces in decoding the brain oxytocin puzzle: Functional insights from mouse brain wiring diagrams.Frontiers in neuroscience · 2022Review
- Ameliorative Effect of Oxytocin onFrontiers in public health · 2022Article
- Do oxytocin neurones affect feeding?Journal of neuroendocrinology · 2021Review
- Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation.International journal of molecular sciences · 2021Review
- Central actions of insulin during pregnancy and lactation.Journal of neuroendocrinology · 2021Review
- Transcription Factor TonEBP Stimulates Hyperosmolality-Dependent Arginine Vasopressin Gene Expression in the Mouse Hypothalamus.Frontiers in endocrinology · 2021Article
- Vitamin D actions in neurons require the PI3K pathway for both enhancing insulin signaling and rapid depolarizing effects.The Journal of steroid biochemistry and molecular biology · 2020Article
- Estrogen receptor-α expressing neurons in the ventrolateral VMH regulate glucose balance.Nature communications · 2020Article
- Metabolic Effects of Oxytocin.Endocrine reviews · 2020Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Neurons in the supraoptic nuclei (SON) produce oxytocin and vasopressin and express insulin receptors (InsR) and glucokinase. Since oxytocin is an anorexigenic agent and glucokinase and InsR are hallmarks of cells that function as glucose and/or metabolic sensors, we evaluated the effect of glucose, insulin, and their downstream effector ATP-sensitive potassium (KATP) channels on calcium signaling in SON neurons and on oxytocin and vasopressin release from explants of the rat hypothalamo-neurohypophyseal system. We also evaluated the effect of blocking glucokinase and phosphatidylinositol 3 kinase (PI3K; mediates insulin-induced mobilization of glucose transporter, GLUT4) on responses to glucose and insulin. Glucose and insulin increased intracellular calcium ([Ca(2+)]i). The responses were glucokinase and PI3K dependent, respectively. Insulin and glucose alone increased vasopressin release (P < 0.002). Oxytocin release was increased by glucose in the presence of insulin. The oxytocin (OT) and vasopressin (VP) responses to insulin+glucose were blocked by the glucokinase inhibitor alloxan (4 mM; P ≤ 0.002) and the PI3K inhibitor wortmannin (50 nM; OT: P = 0.03; VP: P ≤ 0.002). Inactivating K ATP channels with 200 nM glibenclamide increased oxytocin and vasopressin release (OT: P < 0.003; VP: P < 0.05). These results suggest that insulin activation of PI3K increases glucokinase-mediated ATP production inducing closure of K ATP channels, opening of voltage-sensitive calcium channels, and stimulation of oxytocin and vasopressin release. The findings are consistent with SON oxytocin and vasopressin neurons functioning as glucose and "metabolic" sensors to participate in appetite regulation.
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