Evidence map›Paper›PMID 24477514›Full record

Trial reportBiological research for nursing2014

Baseline immune biomarkers as predictors of MBSR(BC) treatment success in off-treatment breast cancer patients.

Richard R Reich, Cecile A Lengacher, Kevin E Kip, Steven C Shivers, Michael J Schell, Melissa M Shelton, Raymond H Widen, Catherine Newton, Michelle K Barta, Carly L Paterson and 3 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Biological research for nursing, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 10 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 10 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  5. Pooled it
  6. Pooled it
  7. Mindfulness-based stress reduction for women diagnosed with breast cancer.The Cochrane database of systematic reviews · 2019
    Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Beyond tumor biology: nursing interventions for psychological and immune health in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Review
  12. Article
  13. Biomarkers as Common Data Elements for Symptom and Self-Management Science.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2018
    Article
  14. Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Richard R ReichCollege of Arts and Sciences, University of South Florida Sarasota-Manatee, Sarasota, FL, USA H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Cecile A LengacherH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA College of Nursing, University of South Florida, Tampa, FL, USA clengach@health.usf.edu.
Kevin E KipCollege of Nursing, University of South Florida, Tampa, FL, USA.
Steven C ShiversUniversity of South Florida Breast Health Clinical and Research Integrated Strategic Program, Tampa, FL, USA.
Michael J SchellH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Melissa M SheltonCollege of Nursing, University of South Florida, Tampa, FL, USA.
Raymond H WidenTampa General Hospital, Tampa, FL, USA.
Catherine NewtonMorsani College of Medicine, University of South Florida, Tampa, FL, USA.
Michelle K BartaCollege of Nursing, University of South Florida, Tampa, FL, USA.
Carly L PatersonCollege of Nursing, University of South Florida, Tampa, FL, USA.
Jerrica R FariasCollege of Nursing, University of South Florida, Tampa, FL, USA.
Charles E CoxUniversity of South Florida Breast Health Clinical and Research Integrated Strategic Program, Tampa, FL, USA Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Thomas W KleinMorsani College of Medicine, University of South Florida, Tampa, FL, USA.
University of South Florida · USMoffitt Cancer Center · USTampa General Hospital · USUniversity of South Florida Sarasota–Manatee · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
Effects of MBSR in Early Stage Breast Cancer RecoveryR21CA109168 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI LENGACHER, CECILE A · 2006 to 2007
$299k
NCI NIH HHS P30 CA076292NCI NIH HHS R21 CA109168NCI NIH HHS R21CA109168
6 · The paper itself

Abstract

Researchers focused on patient-centered medicine are increasingly trying to identify baseline factors that predict treatment success. Because the quantity and function of lymphocyte subsets change during stress, we hypothesized that these subsets would serve as stress markers and therefore predict which breast cancer patients would benefit most from mindfulness-based stress reduction (MBSR)-facilitated stress relief. The purpose of this study was to assess whether baseline biomarker levels predicted symptom improvement following an MBSR intervention for breast cancer survivors (MBSR[BC]). This randomized controlled trial involved 41 patients assigned to either an MBSR(BC) intervention group or a no-treatment control group. Biomarkers were assessed at baseline, and symptom change was assessed 6 weeks later. Biomarkers included common lymphocyte subsets in the peripheral blood as well as the ability of T cells to become activated and secrete cytokines in response to stimulation with mitogens. Spearman correlations were used to identify univariate relationships between baseline biomarkers and 6-week improvement of symptoms. Next, backward elimination regression models were used to identify the strongest predictors from the univariate analyses. Multiple baseline biomarkers were significantly positively related to 6-week symptom improvement. The regression models identified B-lymphocytes and interferon-γ as the strongest predictors of gastrointestinal improvement (p < .01), +CD4+CD8 as the strongest predictor of cognitive/psychological (CP) improvement (p = .02), and lymphocytes and interleukin (IL)-4 as the strongest predictors of fatigue improvement (p < .01). These results provide preliminary evidence of the potential to use baseline biomarkers as predictors to identify the patients likely to benefit from this intervention.

Indexed as

AdultAgedBiomarkers, TumorBreast NeoplasmsFemaleHumansLymphocyte SubsetsMiddle AgedTreatment OutcomeBiomarkers, Tumorbiomarkersbreast cancermindfulness-based stress reduction

Identifiers

PMID24477514
PMCPMC4604564
OpenAlexW2108423652

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.