Observational studyIntensive care medicine2014
Energy expenditure in the critically ill performing early physical therapy.
Observational study in Intensive care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Methodological Aspects of Indirect Calorimetry in Patients with Sepsis-Possibilities and Limitations.Nutrients · 2022Pooled it
- Trial
- Acute effect of passive cycle-ergometry and functional electrical stimulation on nitrosative stress and inflammatory cytokines in mechanically ventilated critically ill patients: a randomized controlled trial.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020Trial
- Comparison of exercise intensity during four early rehabilitation techniques in sedated and ventilated patients in ICU: a randomised cross-over trial.Critical care (London, England) · 2018Trial
- Trial
- TryCYCLE: A Prospective Study of the Safety and Feasibility of Early In-Bed Cycling in Mechanically Ventilated Patients.PloS one · 2016Trial
- The Metabolic Impact of Biodegradable Temporizing Matrix in Burn Patients: A Retrospective Analysis of Resting Energy Expenditure and Inflammation.Journal of burn care & research : official publication of the American Burn Association · 2025Article
- Energy expenditure measurement in critical care: Implications for personalized nutrition support.World journal of critical care medicine · 2025Article
- Article
- Article
- Respiratory Support Adjustments and Monitoring of Mechanically Ventilated Patients Performing Early Mobilization: A Scoping Review.Critical care explorations · 2021Article
- Status of adult inpatient burn rehabilitation in Europe: Are we neglecting metabolic outcomes?Burns & trauma · 2021Article
- Proposal of a new equation for estimating resting energy expenditure of acute kidney injury patients on dialysis: a machine learning approach.Nutrition & metabolism · 2020Article
- The comparison of resting metabolic rate between biopsy-proven non-alcoholic steatohepatitis and non-alcoholic fatty liver patients.Hepatology forum · 2020Article
- Resting Energy Expenditure, Insulin Resistance andFrontiers in endocrinology · 2019Article
- Therapist perceptions of a rehabilitation research study in the intensive care unit: a trinational survey assessing barriers and facilitators to implementing the CYCLE pilot randomized clinical trial.Pilot and feasibility studies · 2019Article
- Article
- Strategies for optimal calorie administration in critically ill patients.Journal of intensive care · 2019Review
- Physical rehabilitation interventions in the intensive care unit: a scoping review of 117 studies.Journal of intensive care · 2018Article
- Associations Between C-Reactive Protein, Insulin Sensitivity, and Resting Metabolic Rate in Adults: A Mediator Analysis.Frontiers in endocrinology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeResting energy expenditure (REE) determination is of high relevance to avoid both overfeeding and underfeeding. We conducted an observational study to determine the impact of early exercise on energy requirements to adjust caloric intake accordingly in critically ill patients.
methodsThis was a prospective observational study conducted in an intensive care unit in 49 hemodynamically stable critically ill patients and 15 healthy volunteers. Indirect calorimetry (IC) was performed for 15 min at baseline during resting conditions, and then continuously recorded during 30 min of cycling at 0, 3, or 6 watts (W), followed by a 15-min resting period. REE determined by IC was compared with predictive formulas and correlated with several biomarkers. The energy cost of early exercise was compared between critically ill patients and healthy volunteers.
resultsIn patients, REE determined by IC was higher than predicted by Harris-Benedict (29 ± 31 %, p < 0.001) and Fleisch equations (23 ± 31 %, p < 0.001) but lower than predicted by the Faisy-Fagon equation for ventilated patients (16 ± 19 %, p < 0.05). Differences between Harris-Benedict predictions and IC determination were positively correlated with C-reactive protein (CRP) in patients with sepsis (r = 0.51, p = 0.003). During a similar exercise, VO2 increase in patients was higher when compared with healthy volunteers at 3 W, close to significant at 6 W, and not present in the passive group.
conclusionsThe critically ill have increased REE according to inflammation defined by CRP. Increased energy requirement for physical activity was only present for active exercise and seems to differ from that in the healthy population. For the exercise duration and intensity tested, nutritional adjustment is not indicated.
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