ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2014
Impact of point spread function modeling and time-of-flight on myocardial blood flow and myocardial flow reserve measurements for rubidium-82 cardiac PET.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Patient-tailored risk assessment of obstructive coronary artery disease using Rubidium-82 PET-based myocardial flow quantification with visual interpretation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- A retrospective evaluation of Bayesian-penalized likelihood reconstruction for [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Machine learning based model to diagnose obstructive coronary artery disease using calcium scoring, PET imaging, and clinical data.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Influence of image reconstruction on quantitative cardiacJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Diagnostic value of regional myocardial flow reserve measurements using Rubidium-82 PET : Disclosures none.The international journal of cardiovascular imaging · 2022Article
- Effect of temporal sampling protocols on myocardial blood flow measurements using Rubidium-82 PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- The next step in improving (semi-)quantitative MPI PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Value of SiPM PET in myocardial perfusion imaging using Rubidium-82.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Test-retest repeatability and software reproducibility of myocardial flow measurements using rest/adenosine stress Rubidium-82 PET/CT with and without motion correction in healthy young volunteers.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Pitfalls on PET/CT Due to Artifacts and Instrumentation.Seminars in nuclear medicine · 2021Review
- Assessment of motion correction in dynamic rubidium-82 cardiac PET with and without frame-by-frame adjustment of attenuation maps for calculation of myocardial blood flow.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- The Importance of Time-of-Flight Reconstruction and Point Spread Modeling in the Measurement of Myocardial Blood Flow Parameters.Current cardiology reports · 2021Review
- EANM procedural guidelines for PET/CT quantitative myocardial perfusion imaging.European journal of nuclear medicine and molecular imaging · 2021Article
- Reproducibility of LVEF, LV volumes, and LV mass between Rubidium-82 PET/CT scans in young healthy volunteers using two commercially available software packages.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Gating Approaches in Cardiac PET Imaging.PET clinics · 2019Review
- Impaired myocardial perfusion is associated with increasing end-systolic- and end-diastolic volumes in patients with non-ischemic systolic heart failure: a cross-sectional study using Rubidium-82 PET/CT.BMC cardiovascular disorders · 2019Article
- The effect of time-of-flight and point spread function modeling onJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Time-of-flight in cardiac PET/TC: What do we know and what we should know?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Impact of pharmacological stress agent on patient motion during rubidium-82 myocardial perfusion PET/CT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Moving towards a better understanding of potential pitfalls in quantitative PET myocardial blood flow.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMyocardial flow reserve (MFR) obtained from dynamic cardiac positron emission tomography (PET) with rubidium-82 (Rb-82) has been shown to be a useful measurement in assessing coronary artery disease. Advanced PET reconstructions with point spread function modeling and time-of-flight have been shown to improve image quality but also have an impact on kinetic analysis of dynamic data. This study aims to determine the impact of these algorithms on MFR data.
methodsDynamic Rb-82 cardiac PET images from 37 patients were reconstructed with standard and advanced reconstructions. Area under curve (AUC) of the blood input function (BIF), myocardial blood flow (MBF) and MFR were compared with each reconstruction.
resultsNo significant differences were seen in MFR for the two reconstructions. A relatively small mean difference in MBF data of +11.9% was observed with advanced reconstruction compared with the standard reconstruction but there was considerable variability in the degree of change (95% confidence intervals of -16.2% to +40.0%). Small systematic relative differences were seen for AUC BIF (mean difference of -6.3%; 95% CI -17.5% to +5.4%).
conclusionMFR results from Rb-82 dynamic PET appear to be robust when generated by standard or advanced PET reconstructions. Considerable increases in MBF values may occur with advanced reconstructions, and further work is required to fully understand this.
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