ArticleMarine drugs2014
Bioactive cembranoids, sarcocrassocolides P-R, from the Dongsha Atoll soft coral Sarcophyton crassocaule.
Article in Marine drugs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Cytotoxic Compounds from Alcyoniidae: An Overview of the Last 30 Years.Marine drugs · 2022Review
- Cherbonolides M and N from a Formosan Soft CoralMarine drugs · 2021Article
- New Hydroquinone Monoterpenoid and Cembranoid-Related Metabolites from the Soft CoralMarine drugs · 2020Article
- Bioactive compounds from marine invertebrates as potent anticancer drugs: the possible pharmacophores modulating cell death pathways.Molecular biology reports · 2020Review
- New Biscembranoids Sardigitolides A-D and Known Cembranoid-Related Compounds fromMarine drugs · 2020Article
- Collective Locomotion of Human Cells, Wound Healing and Their Control by Extracts and Isolated Compounds from Marine Invertebrates.Molecules (Basel, Switzerland) · 2020Review
- Chemical Diversity in Species Belonging to Soft Coral GenusMarine drugs · 2020Review
- Effects of dichloromethaneVeterinary world · 2019Article
- Coral and Coral-Associated Microorganisms: A Prolific Source of Potential Bioactive Natural Products.Marine drugs · 2019Review
- Screening of NO Inhibitor Release Activity from Soft Coral Extracts Origin Palu Bay, Central Sulawesi, Indonesia.Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2019Article
- Isoprenoids from the Soft Coral Sarcophyton glaucum.Marine drugs · 2017Article
- Metabolomics reveals biotic and abiotic elicitor effects on the soft coral Sarcophyton ehrenbergi terpenoid content.Scientific reports · 2017Article
- New Cembrane-Type Diterpenoids from the South China Sea Soft Coral Sarcophyton ehrenbergi.Molecules (Basel, Switzerland) · 2016Article
- Marine Diterpenoids as Potential Anti-Inflammatory Agents.Mediators of inflammation · 2015Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New cembranoids, sarcocrassocolides P-R (1-3) and four known compounds (4-7) were isolated from the soft coral Sarcophyton crassocaule. The structures of the metabolites were determined by extensive spectroscopic analysis. Compounds 3-5 and 7 were shown to exhibit cytotoxicity toward a limited panel of cancer cell lines and all compounds 1-7 displayed potent in vitro anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells by inhibiting the expression of inducible nitric oxide synthase (iNOS) protein. Compound 7 also showed significant activity in reducing the accumulation of cyclooxygenase-2 (COX-2) protein in the same macrophage cells.
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