Evidence map›Paper›PMID 24477211›Full record

ReviewInternational journal of environmental research and public health2014

Cancer cluster investigations: review of the past and proposals for the future.

Michael Goodman, Judy S LaKind, Jerald A Fagliano, Timothy L Lash, Joseph L Wiemels, Deborah M Winn, Chirag Patel, Juliet Van Eenwyk, Betsy A Kohler, Enrique F Schisterman and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in International journal of environmental research and public health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Investigating reports of cancer clusters in Canada: a qualitative study of public health communication practices and investigation procedures.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2022
    Article
  8. Article
  9. A causal inference framework for cancer cluster investigations using publicly available data.Journal of the Royal Statistical Society. Series A, (Statistics in Society) · 2020
    Article
  10. Article
  11. Article
  12. Article
  13. A study of "cancer villages" in Jiangsu Province of China.Environmental science and pollution research international · 2019
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 2 countries.

Michael GoodmanDepartment of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA. mgoodm2@emory.edu.
Judy S LaKindLaKind Associates, LLC, 106 Oakdale Avenue, Catonsville, MD 21228, USA. lakindassoc@comcast.net.
Jerald A FaglianoDivision of Epidemiology, Environmental and Occupational Health, New Jersey Department of Health, P.O. Box 369, Trenton, NJ 08625, USA. Jerald.Fagliano@doh.state.nj.us.
Timothy L LashDepartment of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA. timothy.lee.lash@emory.edu.
Joseph L WiemelsDivision of Cancer Epidemiology, Department of Epidemiology & Biostatistics, School of Medicine, University of California, Helen Diller Family Cancer Research Building, HD 274 1450 3rd Street, San Francisco, MC 0520, San Francisco, CA 94158, USA. Joe.Wiemels@ucsf.edu.
Deborah M WinnDivision of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD 20892, USA. WINNDE@MAIL.NIH.GOV.
Chirag PatelSchool of Medicine, Stanford University, 1265 Welch Road, Stanford, CA 94305, USA. cjp@stanford.edu.
Juliet Van EenwykWashington State Department of Health, P.O. Box 47812, Olympia, WA 98504, USA. juliet.vaneenwyk@doh.wa.gov.
Betsy A KohlerDepartment of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA. bkohler@naaccr.org.
Enrique F SchistermanDepartment of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA. schistee@mail.nih.gov.
Paul AlbertDepartment of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA. albertp@mail.nih.gov.
Donald R MattisonDepartment of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA. mattisond@risksciences.com.
Emory University · USNational Institutes of Health · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USNew Jersey Department of Health · USNorth American Association of Central Cancer Registries · USStanford University · USUCSF Helen Diller Family Comprehensive Cancer Center · USUniversity of Maryland, Baltimore · USUniversity of Ottawa · CAWashington State Department of Health · US

Funding

Environmental and Molecular Epidemiology of Childhood LeukemiaR01ES009137 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 1999 to 2013
$21.1M
CARDIOVASCULAR DISEASE PREVENTION TRAINING PROGRAMT32HL007034 · NHLBI · STANFORD UNIVERSITY · PI GARDNER, CHRISTOPHER D · 1985 to 2020
$8.7M
Surveillance, Epidemiology and End Results (SEER) Program - EmoryN01PC35135 · NCI · EMORY UNIVERSITY · PI WARD, KEVIN · 2007 to 2009
$5.6M
Project 3: Prenatal Exposure, DNA Methylation & Childhood LeukemiaP01ES018172 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 2009 to 2013
$3.7M
ROC Curve MethodologyZIAHD008761 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI SCHISTERMAN, ENRIQUE F. · 2009 to 2021
$2.1M
NCI NIH HHS N01 PC35135NHLBI NIH HHS T32HL007034NIEHS NIH HHS P01ES018172NIEHS NIH HHS R01ES09137
6 · The paper itself

Abstract

Residential clusters of non-communicable diseases are a source of enduring public concern, and at times, controversy. Many clusters reported to public health agencies by concerned citizens are accompanied by expectations that investigations will uncover a cause of disease. While goals, methods and conclusions of cluster studies are debated in the scientific literature and popular press, investigations of reported residential clusters rarely provide definitive answers about disease etiology. Further, it is inherently difficult to study a cluster for diseases with complex etiology and long latency (e.g., most cancers). Regardless, cluster investigations remain an important function of local, state and federal public health agencies. Challenges limiting the ability of cluster investigations to uncover causes for disease include the need to consider long latency, low statistical power of most analyses, uncertain definitions of cluster boundaries and population of interest, and in- and out-migration. A multi-disciplinary Workshop was held to discuss innovative and/or under-explored approaches to investigate cancer clusters. Several potentially fruitful paths forward are described, including modern methods of reconstructing residential history, improved approaches to analyzing spatial data, improved utilization of electronic data sources, advances using biomarkers of carcinogenesis, novel concepts for grouping cases, investigations of infectious etiology of cancer, and "omics" approaches.

Indexed as

Cluster AnalysisForecastingHumansNeoplasms

Identifiers

PMID24477211
PMCPMC3945549
OpenAlexW2138627847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.