ArticleCPT: pharmacometrics & systems pharmacology2014
Identifying tinnitus-related genes based on a side-effect network analysis.
Article in CPT: pharmacometrics & systems pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Pulsatile Tinnitus: A Comprehensive Clinical Approach to Diagnosis and Management.Journal of clinical medicine · 2025Review
- A scoping review of tinnitus research undertaken by New Zealand researchers: Aotearoa-an international hotspot for tinnitus innovation and collaboration.Journal of the Royal Society of New Zealand · 2025Review
- Tinnitus: Clinical Insights in Its Pathophysiology-A Perspective.Journal of the Association for Research in Otolaryngology : JARO · 2024Review
- Noise-induced hearing loss alters potassium-chloride cotransporter KCC2 and GABA inhibition in the auditory centers.Scientific reports · 2024Article
- Noise-Induced Hearing Loss Alters Potassium-Chloride CoTransporter KCC2 and GABA Inhibition in the auditory centers.Research square · 2023Article
- Abnormal Functional Connectivity Within Default Mode Network and Salience Network Related to Tinnitus Severity.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- The α9α10 nicotinic acetylcholine receptor: a compelling drug target for hearing loss?Expert opinion on therapeutic targets · 2022Review
- Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers.Frontiers in aging neuroscience · 2021Review
- Pharmacotherapy of Tinnitus.Current topics in behavioral neurosciences · 2021Review
- The Role of MRI in Diagnosing Neurovascular Compression of the Cochlear Nerve Resulting in Typewriter Tinnitus.AJNR. American journal of neuroradiology · 2017Article
- A Pilot Genome-Wide Association Study Identifies Potential Metabolic Pathways Involved in Tinnitus.Frontiers in neuroscience · 2017Article
- Brain Metabolic Changes in Rats following Acoustic Trauma.Frontiers in neuroscience · 2017Article
- Tinnitus Treatment with Oxytocin: A Pilot Study.Frontiers in neurology · 2017Article
- Tinnitus: perspectives from human neuroimaging.Nature reviews. Neuroscience · 2015Review
- The Management and Outcomes of Pharmacological Treatments for Tinnitus.Current neuropharmacology · 2015Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tinnitus, phantom sound perception, is a worldwide highly prevalent disorder for which no clear underlying pathology has been established and for which no approved drug is on the market. Thus, there is an urgent need for new approaches to understand this condition. We used a network pharmacology side-effect analysis to search for genes that are involved in tinnitus generation. We analyzed a network of 1,313 drug-target pairs, based on 275 compounds that elicit tinnitus as side effect and their targets reported in databases, and used a quantitative score to identify emergent significant targets that were more common than expected at random. Cyclooxigenase 1 and 2 were significant, which validates our approach, since salicylate is a known tinnitus generator. More importantly, we predict previously unknown tinnitus-related targets. The present results have important implications toward understanding tinnitus pathophysiology and might pave the way toward the design of novel pharmacotherapies.CPT Pharmacometrics Syst. Pharmacol. (2014) 3, e97; doi:10.1038/psp.2013.75; published online 29 January 2014.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.