ArticlePublic health nutrition2014
Is vitamin D status associated with open-angle glaucoma? A cross-sectional study from South Korea.
Article in Public health nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Vitamin D and Ocular Diseases: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Pooled it
- Lack of Association between Serum Vitamin B₆, Vitamin BNutrients · 2017Pooled it
- Trial
- Article
- Optimizing serum 25(OH)D levels to mitigate the risk of age-related ocular diseases: insights from a large-scale prospective cohort study.Nutrition journal · 2025Article
- Ocular haemodynamics in children with vitamin D deficiency.Eye (London, England) · 2025Article
- Meta-Analysis: A to Z for Healthcare Professionals.Cureus · 2025Article
- Article
- Vitamin D levels and risk of ocular disorders: insights from bidirectional and multivariable Mendelian randomization analysis.Frontiers in medicine · 2024Article
- Vitamin D, the Vitamin D Receptor, Calcitriol Analogues and Their Link with Ocular Diseases.Nutrients · 2022Review
- Asian Race and Primary Open-Angle Glaucoma: Where Do We Stand?Journal of clinical medicine · 2022Review
- The effect of vitamin D deficiency on the retinal microvasculature: an observational case-control study.Arquivos brasileiros de oftalmologia · 2022Observational
- Reduced 25-hydroxyvitamin D concentration in the aqueous humor of cataract patients with open-angle glaucoma.Scientific reports · 2021Article
- Review
- The Price of Immune Responses and the Role of Vitamin D in the Inner Ear.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2019Review
- Association of severity of primary open-angle glaucoma with serum vitamin D levels in patients of African descent.Molecular vision · 2019Article
- The Relationship between Vitamin D and Glaucoma: A Kangbuk Samsung Health Study.Korean journal of ophthalmology : KJO · 2016Article
- An Overview of Ophthalmologic Survey Methodology in the 2008-2015 Korean National Health and Nutrition Examination Surveys.Korean journal of ophthalmology : KJO · 2015Review
- Metabolome-Wide Association Study of Primary Open Angle Glaucoma.Investigative ophthalmology & visual science · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveOpen-angle glaucoma (OAG) is one of the major chronic diseases involving the optic nerve. However, little is known about the association between vitamin D and OAG. The present study was conducted to test the hypothesis that lower vitamin D status is associated with greater prevalence of OAG.
designCross-sectional study. Multivariable logistic regression was performed to examine the relationship between serum 25-hydroxyvitamin D (25(OH)D) and OAG after adjusting for traditional potential confounders. OAG was defined by the criteria of the International Society for Geographical and Epidemiological Ophthalmology.
settingThe Fifth Korean National Health and Nutrition Examination Survey conducted in 2010-2011. SUBJECTS: Six thousand and ninety-four adult participants randomly selected from 192 surveys in 131 locations in South Korea.
resultsMultivariable-adjusted odds ratios of OAG across quintiles of decreasing 25(OH)D were 1.26, 1.00 (reference), 1.31, 1.36 and 1.69 (P for quadratic trend <0.01). The odds ratio for the lowest 25(OH)D quintile was significantly higher than that for the second quintile (P < 0.01). In addition, we discovered that the predictors for worsening of OAG, such as intraocular pressure or vertical and horizontal cup-to-disc ratios, had a significant relationship with 25(OH)D level.
conclusionsThere was a reverse J-shaped association between 25(OH)D levels and the risk of OAG, with significantly elevated risk at lower 25(OH)D. The findings of this research suggest that vitamin D deficiency should be considered as a potential risk factor for the development of OAG. To our knowledge, the present study is the first one that shows an association between vitamin D status and OAG.
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