ArticleNature2014
Bidirectional developmental potential in reprogrammed cells with acquired pluripotency.
Article in Nature, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 140 citations in OpenAlex.
- Public Response to Scientific Misconduct: Assessing Changes in Public Sentiment Toward the Stimulus-Triggered Acquisition of Pluripotency (STAP) Cell Case via Twitter.JMIR public health and surveillance · 2017Article
- Investigation of the cellular reprogramming phenomenon referred to as stimulus-triggered acquisition of pluripotency (STAP).Scientific reports · 2016Article
- Article
- The Acid Test for Biological Science: STAP Cells, Trust, and Replication.Science and engineering ethics · 2016Article
- Results of an attempt to reproduce the STAP phenomenon.F1000Research · 2016Article
- Making the most of peer review.eLife · 2015Article
- Promotion of Cancer Stem-Like Cell Properties in Hepatitis C Virus-Infected Hepatocytes.Journal of virology · 2015Article
- Failure to replicate the STAP cell phenomenon.Nature · 2015Article
- STAP cells are derived from ES cells.Nature · 2015Article
- Retinal pigment epithelium transplantation: concepts, challenges, and future prospects.Eye (London, England) · 2015Review
- Excellence and the new social contract for science: In search for scientific excellence in a changing environment.EMBO reports · 2015Article
- Reviewing post-publication peer review.Trends in genetics : TIG · 2015Article
- Collateral damage: How a case of misconduct brought a leading Japanese biology institute to its knees.Nature · 2015Article
- Pre- and postmortem imaging of transplanted cells.International journal of nanomedicine · 2015Review
- The Inherent Drawbacks of the Pressure to Publish in Health Sciences: Good or Bad Science.F1000Research · 2015Article
- The molecular underpinnings of totipotency.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Progenitor/stem cells in renal regeneration and mass lesions.International urology and nephrology · 2014Review
- Quality control method for RNA-seq using single nucleotide polymorphism allele frequency.Genes to cells : devoted to molecular & cellular mechanisms · 2014Article
- Human pluripotent stem cell-derived retinal pigmented epithelium in retinal treatment: from bench to bedside.Molecular neurobiology · 2014Review
- Research integrity: Cell-induced stress.Nature · 2014Article
Corrections and comments
- Retraction · 2014-07-02Error in Image · Unreliable Image · Unreliable Results and/or Conclusions ·
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- Retracted
Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We recently discovered an unexpected phenomenon of somatic cell reprogramming into pluripotent cells by exposure to sublethal stimuli, which we call stimulus-triggered acquisition of pluripotency (STAP). This reprogramming does not require nuclear transfer or genetic manipulation. Here we report that reprogrammed STAP cells, unlike embryonic stem (ES) cells, can contribute to both embryonic and placental tissues, as seen in a blastocyst injection assay. Mouse STAP cells lose the ability to contribute to the placenta as well as trophoblast marker expression on converting into ES-like stem cells by treatment with adrenocorticotropic hormone (ACTH) and leukaemia inhibitory factor (LIF). In contrast, when cultured with Fgf4, STAP cells give rise to proliferative stem cells with enhanced trophoblastic characteristics. Notably, unlike conventional trophoblast stem cells, the Fgf4-induced stem cells from STAP cells contribute to both embryonic and placental tissues in vivo and transform into ES-like cells when cultured with LIF-containing medium. Taken together, the developmental potential of STAP cells, shown by chimaera formation and in vitro cell conversion, indicates that they represent a unique state of pluripotency.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.