ArticleNature2014
Stimulus-triggered fate conversion of somatic cells into pluripotency.
Article in Nature, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 92 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
92 citing papers in PubMed.
- Characterizing the effect of retractions on publishing careers.Nature human behaviour · 2025Article
- Stem cell therapy for retinal pigment epithelium disorders.World journal of stem cells · 2025Review
- Induced pluripotent stem cell technology for spinal cord injury: a promising alternative therapy.Neural regeneration research · 2021Article
- Double sperm cloning (DSC) is a promising strategy in mammalian genetic engineering and stem cell research.Stem cell research & therapy · 2020Review
- Human adult pluripotency: Facts and questions.World journal of stem cells · 2019Article
- The limited application of stem cells in medicine: a review.Stem cell research & therapy · 2018Review
- Keloid progression: a stiffness gap hypothesis.International wound journal · 2017Article
- Public Response to Scientific Misconduct: Assessing Changes in Public Sentiment Toward the Stimulus-Triggered Acquisition of Pluripotency (STAP) Cell Case via Twitter.JMIR public health and surveillance · 2017Article
- Scientific Misconduct and Social Media: Role of Twitter in the Stimulus Triggered Acquisition of Pluripotency Cells Scandal.Journal of medical Internet research · 2017Article
- Irreproducibility of published bioscience research: Diagnosis, pathogenesis and therapy.Molecular metabolism · 2017Article
- Canon Fodder-A Case for Contrarian Science.Circulation research · 2016Review
- Analysis of chromosomal aberrations and recombination by allelic bias in RNA-Seq.Nature communications · 2016Article
- Acidic extracellular pH of tumors induces octamer-binding transcription factor 4 expression in murine fibroblasts in vitro and in vivo.Scientific reports · 2016Article
- Investigation of the cellular reprogramming phenomenon referred to as stimulus-triggered acquisition of pluripotency (STAP).Scientific reports · 2016Article
- The Acid Test for Biological Science: STAP Cells, Trust, and Replication.Science and engineering ethics · 2016Article
- Ensuring the Quality, Fairness, and Integrity of Journal Peer Review: A Possible Role of Editors.Science and engineering ethics · 2016Article
- Results of an attempt to reproduce the STAP phenomenon.F1000Research · 2016Article
- Making the most of peer review.eLife · 2015Article
- Promotion of Cancer Stem-Like Cell Properties in Hepatitis C Virus-Infected Hepatocytes.Journal of virology · 2015Article
- Clothes Do Not Make the Man: Well-favored Figures are Game-changers in the Biomedical Publication.Journal of Korean medical science · 2015Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
- Retraction · 2014-07-02Error in Image · Investigation by Company/Institution · Unreliable Image · Unreliable Results and/or Conclusions ·
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- Retracted
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we report a unique cellular reprogramming phenomenon, called stimulus-triggered acquisition of pluripotency (STAP), which requires neither nuclear transfer nor the introduction of transcription factors. In STAP, strong external stimuli such as a transient low-pH stressor reprogrammed mammalian somatic cells, resulting in the generation of pluripotent cells. Through real-time imaging of STAP cells derived from purified lymphocytes, as well as gene rearrangement analysis, we found that committed somatic cells give rise to STAP cells by reprogramming rather than selection. STAP cells showed a substantial decrease in DNA methylation in the regulatory regions of pluripotency marker genes. Blastocyst injection showed that STAP cells efficiently contribute to chimaeric embryos and to offspring via germline transmission. We also demonstrate the derivation of robustly expandable pluripotent cell lines from STAP cells. Thus, our findings indicate that epigenetic fate determination of mammalian cells can be markedly converted in a context-dependent manner by strong environmental cues.
Indexed as
Identifiers
24476887What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.