Trial reportReproductive biology and endocrinology : RB&E2014
Effect of intrauterine injection of human chorionic gonadotropin before embryo transfer on clinical pregnancy rates from in vitro fertilisation cycles: a prospective study.
Trial report in Reproductive biology and endocrinology : RB&E, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01986374 (Intrauterine Injection of Human Chorionic Gonadotropin to Enhance Embryo Implantation), which is not on this map. Cited by 27 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intrauterine Injection of Human Chorionic Gonadotropin to Enhance Embryo Implantation
Who cites it
27 citing papers in PubMed, 6 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Uterine infusion strategies for infertile patients with recurrent implantation failure: a systematic review and network meta-analysis.Reproductive biology and endocrinology : RB&E · 2024Pooled it
- Does Intrauterine Injection of hCG Improve IVF Outcome? A Systematic Review and a Meta-Analysis.International journal of molecular sciences · 2022Pooled it
- Interventions to optimize embryo transfer in women undergoing assisted conception: a comprehensive systematic review and meta-analyses.Human reproduction update · 2022Pooled it
- Intrauterine administration of human chorionic gonadotropin (hCG) for subfertile women undergoing assisted reproduction.The Cochrane database of systematic reviews · 2018Pooled it
- Luteal phase support for assisted reproduction cycles.The Cochrane database of systematic reviews · 2015Pooled it
- Investigating the Optimal Time for Intrauterine Human Chorionic Gonadotropin Infusion in Order to Improve IVF Outcome: A Systematic Review and Meta-Analysis.In vivo (Athens, Greece)Pooled it
- Effect of intrauterine administration of human chorionic gonadotropin one day before fresh blastocyst transfer on clinical outcomes: a quasi-experimental study.The Pan African medical journal · 2022Trial
- Intrauterine human chorionic gonadotropin infusion in oocyte donors promotes endometrial synchrony and induction of early decidual markers for stromal survival: a randomized clinical trial.Human reproduction (Oxford, England) · 2016Trial
- Intrauterine administration of human chorionic gonadotropin does not improve pregnancy and life birth rates independently of blastocyst quality: a randomised prospective study.Reproductive biology and endocrinology : RB&E · 2015Trial
- When to test: defining the earliest reliable time for pregnancy detection and its prognostic value after frozen embryo transfer.AJOG global reports · 2026Article
- The Effect of Intramuscular Human Chorionic Gonadotropin on Endometrial Preparation in Frozen-Thawed Embryo Transfer: A Randomized Clinical Trial.International journal of fertility & sterility · 2026Article
- Mechanism of human chorionic gonadotropin in endometrial receptivity via the miR-126-3p/PI3K/Akt/eNOS axis.The Kaohsiung journal of medical sciences · 2023Article
- Effect of intramuscular injection of human chorionic gonadotropin on endometrium preparation in frozen-thawed embryo transfer cycle: A randomized clinical trial.Caspian journal of internal medicine · 2023Article
- The effect of intrauterine hCG injection before embryo transfer on pregnancy rate in frozen embryo transfer cycles.Annals of medicine and surgery (2012) · 2022Article
- Epithelial-mesenchymal transition process during embryo implantation.Cell and tissue research · 2022Review
- Human Chorionic Gonadotropin and Early Embryogenesis: Review.International journal of molecular sciences · 2022Review
- Approaches to Improve Endometrial Receptivity in Case of Repeated Implantation Failures.Frontiers in cell and developmental biology · 2021Review
- Intramuscular injection of human chorionic gonadotropin prior to secretory transformation in patients undergoing frozen-thawed embryo transfer cycles.Reproductive biology and endocrinology : RB&E · 2020Article
- Human Chorionic Gonadotrophin: New Pleiotropic Functions for an "Old" Hormone During Pregnancy.Frontiers in immunology · 2020Review
- The Effect of Intrauterine Administration of Human Chorionic Gonadotropin (hCG) Before Embryo Transfer During Assisted Reproductive Cycles: a Meta-Analysis of Randomized Controlled Trials.Geburtshilfe und Frauenheilkunde · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe implantation process after embryo transfer depends on the embryo quality and endometrial receptivity. It is estimated that fifty to seventy-five per cent of pregnancies are lost due to a failure of implantation. There is evidence that there is an early secretion of human chorionic gonadotrophin before embryo implantation, and this secretion has been linked to an important function in angiogenesis and the inflammatory response that promotes the implantation process. Our objective was to determine the effects of intrauterine injection of human chorionic gonadotropin (hCG) before the embryo transfer in an in vitro fertilisation cycle.
methodsA prospective randomised study was conducted in Reproductive Medicine Centre PROCREA in Mexico City. Infertile patients who had a medical indication for in vitro fertilisation were studied. Two groups were included (n 210); the intervention group received an intrauterine injection of 500 IU of hCG before the embryo transfer (n 101). The control group (n 109) did not receive hCG. Comparisons were performed using a chi-square test.
resultsThe clinical pregnancy rate (CPR) was our principal outcome. The implantation rate was a secondary outcome. The implantation rate was significantly higher in the hCG group compared to the control group (52.4% vs 35.7%, p 0.014). The clinical pregnancy rate was also significantly higher (50.4 vs 33.0%, p 0.010). No adverse effects were observed.
conclusionsThe intrauterine injection of hCG before embryo transfer showed a significant increase in the clinical pregnancy rate. More clinical trials are needed to reproduce these results on this promising intervention. The live birth rate must be included in subsequent studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.