ReviewNutrition journal2014
Modulation of obesity-induced inflammation by dietary fats: mechanisms and clinical evidence.
Review in Nutrition journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it, 139 citations in OpenAlex.
- The association between body fat and musculoskeletal pain: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2018Pooled it
- Interplay of Postprandial Triglyceride-Rich Lipoprotein Composition and Adipokines in Obese Adolescents.International journal of molecular sciences · 2024Trial
- Resistant starch lowers postprandial glucose and leptin in overweight adults consuming a moderate-to-high-fat diet: a randomized-controlled trial.Nutrition journal · 2017Trial
- Does chronic physical activity level modify the airway inflammatory response to an acute bout of exercise in the postprandial period?Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2017Trial
- Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity.Nutrition journal · 2016Trial
- Effects of n-3 polyunsaturated fatty acids (ω-3) supplementation on some cardiovascular risk factors with a ketogenic Mediterranean diet.Marine drugs · 2015Trial
- Decoding Immunometabolic Dynamics of Adipose Tissue in Obesity: Evolving Evidence and Way Forward.ACS pharmacology & translational science · 2026Review
- Palmitic acid intake in children on gluten-free and generalized diets before and after palm oil reformulation: nutritional and metabolic implications.Frontiers in nutrition · 2026Article
- Effects of switching from a high-fat diet to a ketogenic diet on oxidative stress, nitrosative damage, and protein glycation in rat skin.Frontiers in immunology · 2026Article
- Gender specific associations and interactions of fat quality with sleep and mental health in the elderly.Journal of health, population, and nutrition · 2025Article
- Postprandial Inflammation in Obesity: Dietary Determinants, Adipose Tissue Dysfunction and the Gut Microbiome.Biomolecules · 2025Review
- Icosapent ethyl-induced lipoprotein remodeling and its impact on cardiovascular disease risk markers in normolipidemic individuals.JCI insight · 2025Article
- Intakes of saturated and unsaturated fat and circulating levels of inflammatory markers among breast cancer survivors.Scientific reports · 2025Article
- Effects of increasing n3:n6 ratio by replacing extruded soybeans with extruded flaxseed on dry matter intake, rumen fluid bacteria, and liver lipid metabolism in transition cows.BMC microbiology · 2025Article
- Reframing Diabetes Prevention: From Body Shaming to Metabolic Reprogramming.American journal of lifestyle medicine · 2025Review
- Nutritional Status of Vitamin E and Its Association with Metabolic Health in Adults.Nutrients · 2025Article
- The Role of Unsaturated Fatty Acid-Rich Dairy Products in Adipocyte Metabolism.Molecules (Basel, Switzerland) · 2024Article
- Obesity Arrhythmias: Role of IL-6 Trans-Signaling.International journal of molecular sciences · 2024Review
- The Metabolic Syndrome, a Human Disease.International journal of molecular sciences · 2024Review
- Avocado consumption and markers of inflammation: results from the Multi-Ethnic Study of Atherosclerosis (MESA).European journal of nutrition · 2023Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity plays a pivotal role in the development of low-grade inflammation. Dietary fatty acids are important modulators of inflammatory responses. Saturated fatty acids (SFA) and n-6 polyunsaturated fatty acids (PUFA) have been reported to exert pro-inflammatory effects. n-3 PUFA in particular, possess anti-inflammatory properties. Numerous clinical studies have been conducted over decades to investigate the impact of dietary fatty acids on inflammatory response in obese individuals, however the findings remained uncertain. High fat meals have been reported to increase pro-inflammatory responses, however there is limited evidence to support the role of individual dietary fatty acids in a postprandial state. Evidence in chronic studies is contradictory, the effects of individual dietary fatty acids deserves further attention. Weight loss rather than n-3 PUFA supplementation may play a more prominent role in alleviating low grade inflammation. In this context, the present review provides an update on the mechanistic insight and the influence of dietary fats on low grade inflammation, based on clinical evidence from acute and chronic clinical studies in obese and overweight individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.