ArticleNeurogastroenterology and motility2014
Reproducibility patterns of multiple rapid swallows during high resolution esophageal manometry provide insights into esophageal pathophysiology.
Article in Neurogastroenterology and motility, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Guideline
- Optimizing Assessment of Contraction Reserve in Ineffective Esophageal Motility: A Study of Upright Multiple Rapid Swallows.Journal of neurogastroenterology and motility · 2025Article
- Integrated Relaxation Pressure and Its Diagnostic Ability May Vary According to the Conditions Used for HREM Recording.Dysphagia · 2024Article
- Effect of inter-swallow interval on striated esophagus peristalsis; a comparative study with smooth muscle esophagus.Neurogastroenterology and motility · 2023Article
- The Supportive Role of Provocative Maneuvers and Impedance Clearance in Detecting Ineffective Esophageal Motility.Gastroenterology research · 2022Article
- Evaluation of esophageal motor function in patients with gastroesophageal reflux using multiple rapid swallows.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021Article
- Chicago classification version 4.0Neurogastroenterology and motility · 2021Review
- Patterns of esophageal dysmotility elicited by multiple rapid swallows.Esophagus : official journal of the Japan Esophageal Society · 2021Article
- Assessment of the Multiple Rapid Swallows Test for Gauging Esophageal Reflux Burden in Patients with Refractory Gastroesophageal Reflux Disease.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Normal Functional Luminal Imaging Probe Panometry Findings Associate With Lack of Major Esophageal Motility Disorder on High-Resolution Manometry.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021Article
- High-Resolution Manometry-Observations After 15 Years of Personal Use-Has Advancement Reached a Plateau?Current gastroenterology reports · 2020Review
- Lower oesophageal sphincter identification for gastro-oesophageal reflux monitoring: The step-up method revisited with use of basal impedance.United European gastroenterology journal · 2019Article
- Multiple Rapid Swallows (MRS) Complements Single-Swallow (SS) Analysis for High-Resolution Esophageal Manometry (HREM).Digestive diseases and sciences · 2019Article
- Advances in Management of Esophageal Motility Disorders.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2018Review
- Multiple rapid swallow testing in patients with gastroesophageal reflux disease.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2018Article
- Review
- Impact of symptom burden and health-related quality of life (HRQOL) on esophageal motor diagnoses.Neurogastroenterology and motility · 2017Article
- Chicago Classification of Esophageal Motility Disorders: Applications and Limits in Adults and Pediatric Patients with Esophageal Symptoms.Current gastroenterology reports · 2016Review
- Ineffective esophageal motility phenotypes following fundoplication in gastroesophageal reflux disease.Neurogastroenterology and motility · 2016Article
- Exaggerated smooth muscle contraction segments on esophageal high-resolution manometry: prevalence and clinical relevance.Neurogastroenterology and motility · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMultiple rapid swallows (MRS) during esophageal high resolution manometry (HRM) assess esophageal neuromuscular integrity by evaluating postdeglutitive inhibition and rebound contraction, but most reports performed only a single MRS sequence. We assessed patterns of MRS reproducibility during clinical HRM in comparison to a normal cohort.
methodsConsecutive clinical HRM studies were included if two separate MRS sequences (four to six rapid swallows ≤4 s apart) were successfully performed. Chicago Classification diagnoses were identified; contraction wave abnormalities were additionally recorded. MRS-induced inhibition (contraction ≤3 cm during inhibition phase) and rebound contraction was assessed, and findings compared to 18 controls (28.0 ± 0.7 year, 50.0% female). Reproducibility consisted of similar inhibition and contraction responses with both sequences; discordance was segregated into inhibition and contraction phases. KEY
resultsMultiple rapid swallows were successfully performed in 89.3% patients and all controls; 225 subjects (56.2 ± 0.9 year, 62.7% female) met study inclusion criteria. Multiple rapid swallows were reproducible in 76.9% patients and 94.4% controls (inhibition phase: 88.0% vs 94.4%, contraction phase 86.7% vs 100%, respectively, p = ns). A gradient of reproducibility was noted, highest in well-developed motor disorders (achalasia spectrum, hypermotility disorders, and aperistalsis, 91.7-100%, p = ns compared to controls); and lower in lesser motor disorders (contraction wave abnormalities, esophageal body hypomotility) or normal studies (62.2-70.8%, p < 0.0001 compared to well-developed motor disorders). Inhibition phase was most discordant in contraction wave abnormalities, while contraction phase was most discordant when studies were designated normal. CONCLUSIONS & INFERENCES: Multiple rapid swallows are highly reproducible, especially in well-developed motor disorders, and complement the standard wet swallow manometry protocol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.