ArticleVeterinary research2014
Placental thrombosis in acute phase abortions during experimental Toxoplasma gondii infection in sheep.
Article in Veterinary research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Fetal and neonatal demise in zoonotic diseases: pathology and pathogenesis.Infection and immunity · 2026Review
- Evaluating Toxoplasmosis Molecular Prevalence in Slaughtered Sheep using PCR Assay in Northern Palestine.Acta parasitologica · 2026Article
- A safe and efficacious inactivated vaccine aids prevent reproductive failure associated with congenital toxoplasmosis in ovine.Veterinary research · 2026Article
- Early dynamics of Toxoplasma gondii infection in sheep inoculated at mid-gestation with archetypal type II oocysts.Veterinary research · 2025Article
- A combination of GRA3, GRA6 and GRA7 peptides offer a useful tool for serotyping type II and IIIFrontiers in cellular and infection microbiology · 2024Article
- Advances in vaccine development and the immune response against toxoplasmosis in sheep and goats.Frontiers in veterinary science · 2022Review
- Unifying Virulence Evaluation inFrontiers in cellular and infection microbiology · 2022Review
- Toxoplasma Effectors that Affect Pregnancy Outcome.Trends in parasitology · 2021Review
- The Role and Function of Regulatory T Cells inJournal of immunology research · 2021Review
- Isolation and genetic characterization of Toxoplasma gondii in Spanish sheep flocks.Parasites & vectors · 2020Article
- Molecular survey for cyst-forming coccidia (Toxoplasma gondii, Neospora caninum, Sarcocystis spp.) in Mediterranean periurban micromammals.Parasitology research · 2020Article
- Modeling the Ruminant Placenta-Pathogen Interactions in Apicomplexan Parasites: Current and Future Perspectives.Frontiers in veterinary science · 2020Review
- Effective Nanoparticle-Based Nasal Vaccine Against Latent and Congenital Toxoplasmosis in Sheep.Frontiers in immunology · 2020Article
- Isolation, Genotyping, and Mouse Virulence Characterization ofFrontiers in veterinary science · 2020Article
- Peripheral and placental immune responses in sheep after experimental infection with Toxoplasma gondii at the three terms of gestation.Veterinary research · 2019Article
- Treatment with Bumped Kinase Inhibitor 1294 Is Safe and Leads to Significant Protection against Abortion and Vertical Transmission in Sheep Experimentally Infected with Toxoplasma gondii during Pregnancy.Antimicrobial agents and chemotherapy · 2019Article
- Review
- Virulence in Mice of aFrontiers in cellular and infection microbiology · 2018Article
- Report of an unsual case of anophthalmia and craniofacial cleft in a newborn with Toxoplasma gondii congenital infection.BMC infectious diseases · 2017Article
- Factors Associated WithThe East African health research journal · 2017Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After oral administration of ewes during mid gestation with 2000 freshly prepared sporulated oocysts of T. gondii isolate M4, abortions occurred between days 7 and 11 in 91.6% of pregnant and infected ewes. Afterwards, a further infection was carried out at late gestation in another group of sheep with 500 sporulated oocysts. Abortions happened again between days 9 and 11 post infection (pi) in 58.3% of the infected ewes. Classically, abortions in natural and experimental ovine toxoplasmosis usually occur one month after infection. Few experimental studies have reported the so-called acute phase abortions as early as 7 to 14 days after oral inoculation of oocysts, and pyrexia was proposed to be responsible for abortion, although the underline mechanism was not elucidated. In the present study, all placentas analysed from ewes suffering acute phase abortions showed infarcts and thrombosis in the caruncullar villi of the placentomes and ischemic lesions (periventricular leukomalacia) in the brain of some foetuses. The parasite was identified by PCR in samples from some placentomes of only one sheep, and no antigen was detected by immunohistochemical labelling. These findings suggest that the vascular lesions found in the placenta, and the consequent hypoxic damage to the foetus, could be associated to the occurrence of acute phase abortions. Although the pathogenesis of these lesions remains to be determined, the infectious dose or virulence of the isolate may play a role in their development.
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Registered trials
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