ArticleJournal of nephropathology2013
Histological patterns of idiopathic steroid resistant nephrotic syndrome in Egyptian children: A single centre study.
Article in Journal of nephropathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Subclinical systolic dysfunction in children with steroid-resistant nephrotic syndrome identified by speckle tracking echocardiography.BMC pediatrics · 2025Article
- Trends in the epidemiology of childhood nephrotic syndrome in Africa: A systematic review.Global epidemiology · 2021Review
- Trends in the histopathology of childhood nephrotic syndrome in Ibadan Nigeria: preponderance of idiopathic focal segmental glomerulosclerosis.BMC nephrology · 2015Article
- Brain and Lung Abscesses in a 48-year-old Man with Focal and Segmental Glomerulosclerosis.Journal of clinical and diagnostic research : JCDR · 2015Article
- MDR1 polymorphisms and idiopathic nephrotic syndrome in Slovak children: preliminary results.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Thrombotic microangiopathy in IgA nephropathy.Iranian Red Crescent medical journal · 2013Article
- Anti-phospholipase A2 receptor antibody in idiopathic membranous nephropathy: New concepts.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013Article
- Association of proteinuria with various clinical findings and morphologic variables of oxford classification in immunoglobulin a nephropathy patients.International journal of preventive medicine · 2013Article
- R: Histological patterns of idiopathic steroid resistant nephrotic syndrome in Egyptian children: A single centre study.Journal of nephropathology · 2013Article
- Immunoglobulin A Nephropathy and Malaria falciparum Infection; a Rare Association.Iranian journal of public health · 2013Article
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4 authors at 1 institution in 1 country.
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Abstract
background
backgroundIdiopathic steroid resistant nephrotic syndrome (ISRNS) represents about 10-20% of children with nephrotic syndrome with variable outcome.
objectivesTo determine the histological patterns of ISRNS in Egyptian children and the histological details of the commonest types which might be the reason for the steroid resistance. PATIENTS AND
methodsThe study included 53 cases with ISRNS. Their renal biopsies were retrieved from the archive of Electron microscopy unit and pathology department, Ain Shams University Specialized Hospital (ASUSH) in the duration from 2005-2011. The biopsies were examined histologically, with immunohistochemistry, and by electron microscopy.
resultsThey were 36 males (67.9%) and 17 females (32.1%), the age at diagnosis ranged from 1.5- 16 years with a mean of 6.71 years. Lower limb oedema was the commonest presentation (100%), haematuria was revealed in (17%) of cases. Histological examination showed three major patterns; Focal segmental glomerulosclerosis (FSGS) in 30.2%, minimal change glomerulopathy (MCG) in 24.5% and IgA nephropathy in 13.2 %. Mesangial hypercellularity was very common among MCG patients (85.3% ±6.7). Tubulointerstitial inflammation and fibrosis were common among cases with IgA nephropathy (40.4% ±11, 53.7% ±8 respectively).
conclusionsISRNS in Egyptian children could be attributed mainly to three major diseases (FSGS, MCG and IgA nephropathy). Mesangial hypercellularity and severe tubulointerstitial disease might be the major causes for steroid resistance in MCG and IgA nephropathy respectively. Renal biopsy with electron microscopy examination should be done for all children with nephrotic syndrome at first time of presentation for proper assignment of treatment protocol.
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