ArticleJournal of nephropathology2012
Erythropoietin ameliorates genetamicin-induced renal toxicity: A biochemical and histopathological study.
Article in Journal of nephropathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 68 citations in OpenAlex.
- The α7 nicotinic acetylcholine receptor agonist PNU-282987 ameliorates sepsis-induced acute kidney injury through CD4+CD25+ regulatory T cells in rats.Bosnian journal of basic medical sciences · 2022Article
- Renoprotective effect of erythropoietin in zebrafish after administration of gentamicin: an immunohistochemical study for β-catenin and c-kit expression.Journal of nephrology · 2017Article
- Cisplatin-Induced Nephrotoxicity; Protective Supplements and Gender DifferencesAsian Pacific journal of cancer prevention : APJCP · 2017Review
- Comment on: Pomegranate Flower Extract Does Not Prevent Cisplatin-induced Nephrotoxicity in Female Rats.International journal of preventive medicine · 2015Article
- Lack of nephroprotective efficacy of althaea officinalis flower extract against gentamicin renal toxicity in male rats.International journal of preventive medicine · 2014Article
- Ameliorative effect of melatonin against contrast media induced renal tubular cell injury.Pakistan journal of medical sciences · 2014Article
- Renal Cell Protection of Erythropoietin beyond Correcting The Anemia in Chronic Kidney Disease Patients.Cell journal · 2014Article
- Re: Erythropoietin ameliorates oxidative stress and tissue injury following renal ischemia/reperfusion in rat kidney and lung.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2014Article
- Effect of normobaric hyperoxia on gentamicin-induced nephrotoxicity in rats.Iranian journal of basic medical sciences · 2014Article
- Erythropoietin and renal protection.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2013Article
- Comment on: Protective Role of Recombinant Human Erythropoietin in Kidney and Lung Injury Following Renal Bilateral Ischemia-reperfusion in Rat Model.International journal of preventive medicine · 2013Article
- Vacuolization, dilatation, hyaline cast, debris or degeneration: which one is the most correlated item to score the kidney damage pathologically in Cisplatin induced nephrotoxicity model?Nephro-urology monthly · 2013Article
- Comment on: preventive effect of Teucrium polium on learning and memory deficits in diabetic rats.Medical science monitor basic research · 2013Article
- The effects of vitamin E and selenium on cisplatin-induced nephrotoxicity in cancer patients treated with cisplatin-based chemotherapy: A randomized, placebo-controlled study.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013Article
- Oxidative stress and the paradoxical effects of antioxidants.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013Article
- Comment on: The Protective Role of Silymarin and Deferoxamine Against Iron Dextran-Induced Renal Iron Deposition in Male Rats.International journal of preventive medicine · 2013Article
- Commentary on: Effects of Cinnamon Consumption on Glycemic Status, Lipid Profile and Body Composition in Type 2 Diabetic Patients.International journal of preventive medicine · 2013Article
- Preventive and curative effects of ginger extract against histopathologic changes of gentamicin-induced tubular toxicity in rats.International journal of preventive medicine · 2013Article
- Efficacy of Co-administration of Garlic Extract and Metformin for Prevention of Gentamicin-Renal Toxicity in Wistar Rats: A Biochemical Study.International journal of preventive medicine · 2013Article
- Comment on: Anti-Oxidative Stress Activity of Stachys lavandulifolia Aqueous Extract in Humans.Cell journal · 2013Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInvestigations have attempted to modify the outcome of tubular injury by either ameliorating renal tubular damage or promoting tubular regeneration in the case of acute tubular necrosis.
objectivesWe investigated the protective effect of Eprex an erythropoietin analogue on tubular injury induced by gentamicin (GM). MATERIALS AND
methodsForty male Wistar rats were randomly divided into four groups. In group 1,rats were served as a sham group. In group 2, rats were injected intraperitoneally with 100 mg/kg of GM for 10 consecutive days (positive control group) and then were sacrificed. In group 3, rats received GM for 10 days then Eprex 100U/kg was injected intraperitoneally for the next 10 days and then they were sacrificed at the day 20th. In group 4 rats were injected a combination of GM (80 mg/kg) and Eprex 100U/kg intraperitoneally for 10 days and then were sacrificed.
resultsThe results indicated that, Eprex prevented the increase in serum creatinine (Cr) and blood urea nitrogen (BUN). The effect of Eprex on damage score, showed that co-administration of GM and Eprex (group 3 and 4) reduced the kidney tissue damage compared to positive control group (P<0.05). This result indicat that Eprex potentially can reduce or prevent the kidney tissue damage.
conclusionsAmeliorative effect of Eprex when the drug was given in combination with GM and also when the drug was applied after GM-induced tubular damage, revealed the renoprotective potency of Eprex. Eprex is a promising drug to prevent or attenuate tubular damage induced by GM or other nephrotoxic agents which act through the same mechanisms as gentamicin.
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