ArticleMobile genetic elements2013
Continuing analysis of microRNA origins: Formation from transposable element insertions and noncoding RNA mutations.
Article in Mobile genetic elements, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- A noncanonical Pol III-dependent, Microprocessor-independent biogenesis pathway generates a germline-enriched miRNA family.Genes & development · 2025Article
- Identification and Characterization of LINE and SINE Retrotransposons in the African Hedgehog (Genes · 2025Article
- SARS-Cov-2 small viral RNA suppresses gene expression via complementary binding to mRNA 3' UTR.microPublication biology · 2024Article
- Perspective for Studying the Relationship of miRNAs with Transposable Elements.Current issues in molecular biology · 2023Article
- Characterization of a novel sRNA contributing to biofilm formation inmicroPublication biology · 2023Article
- Retrotransposons as Drivers of Mammalian Brain Evolution.Life (Basel, Switzerland) · 2021Review
- Transposable element-derived sequences in vertebrate development.Mobile DNA · 2021Review
- Locus-specific analysis of Transposable Elements during the progression of ALS in the SOD1G93A mouse model.PloS one · 2021Article
- Expression Analyses of MicroRNAs in Hamster Lung Tissues Infected by SARS-CoV-2.Molecules and cells · 2020Article
- LINE-2 transposable elements are a source of functional human microRNAs and target sites.PLoS genetics · 2019Article
- Transposable Elements in Human Cancer: Causes and Consequences of Deregulation.International journal of molecular sciences · 2017Review
- PlanTE-MIR DB: a database for transposable element-related microRNAs in plant genomes.Functional & integrative genomics · 2016Article
- The role of Alu elements in the cis-regulation of RNA processing.Cellular and molecular life sciences : CMLS · 2015Review
- Identification of Novel and Conserved microRNAs in Homalodisca vitripennis, the Glassy-Winged Sharpshooter by Expression Profiling.PloS one · 2015Article
- A Deluge of Complex Repeats: The Solanum Genome.PloS one · 2015Article
- Burgeoning evidence indicates that microRNAs were initially formed from transposable element sequences.Mobile genetic elements · 2014Review
- Transposable elements and small RNAs: Genomic fuel for species diversity.Mobile genetic elementsArticle
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRs) are small noncoding RNAs that typically act as regulators of gene expression by base pairing with the 3' UTR of messenger RNAs (mRNAs) and either repressing their translation or initiating degradation. As of this writing over 24,500 distinct miRs have been identified, but the functions of the vast majority of these remain undescribed. This paper represents a summary of our in depth analysis of the genomic origins of miR loci, detailing the formation of 1,213 of the 7,321 recently identified miRs and thereby bringing the total number of miR loci with defined molecular origin to 3,605. Interestingly, our analyses also identify evidence for a second, novel mechanism of miR locus generation through describing the formation of 273 miR loci from mutations to other forms of noncoding RNAs. Importantly, several independent investigations of the genomic origins of miR loci have now supported the hypothesis that miR hairpins are formed by the adjacent genomic insertion of two complementary transposable elements (TEs) into opposing strands. While our results agree that subsequent transcription over such TE interfaces leads to the formation of the majority of functional miR loci, we now also find evidence suggesting that a subset of miR loci were actually formed by an alternative mechanism-point mutations in other structurally complex, noncoding RNAs (e.g., tRNAs and snoRNAs).
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