ArticleInfection & chemotherapy2013
High In Vitro Infectivity of a Doxycycline-Insensitive Strain of Orientia tsutsugamushi.
Article in Infection & chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Antibiotic Antagonism inInfection & chemotherapy · 2026Review
- Orientia tsutsugamushi: An Unusual Intracellular Bacteria-Adaptation Strategies, Available Antibiotics, and Alternatives for Treatment.Current microbiology · 2024Review
- Molecular diagnosis and genotyping ofFrontiers in tropical diseases · 2023Article
- Monitoring Chigger Mites for Orientia tsutsugamushi in Field Small Mammals in Hwaseong-si, Gyeonggi-do, Korea, 2019-2020.The Korean journal of parasitology · 2021Article
- Scrub Typhus and the Misconception of Doxycycline Resistance.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Review
- Clinical Characteristics and Outcome of Children Hospitalized With Scrub Typhus in an Area of Endemicity.Journal of the Pediatric Infectious Diseases Society · 2020Article
- History of Tsutsugamushi Disease in Korea.Infection & chemotherapy · 2019Review
- A Review of Scrub Typhus (Orientia tsutsugamushi and Related Organisms): Then, Now, and Tomorrow.Tropical medicine and infectious disease · 2018Review
- The Historical Case for and the Future Study of Antibiotic-Resistant Scrub Typhus.Tropical medicine and infectious disease · 2017Review
- In vitro Synergism between Chloroquine and Antibiotics against Orientia tsutsugamushi.Infection & chemotherapy · 2014Article
- In vitro Antagonism between Cefotaxime and Anti-Rickettsial Antibiotics against Orientia tsutsugamushi.Infection & chemotherapy · 2014Article
- Risk Factors for Acquiring Scrub Typhus among the Adults.Journal of global infectious diseasesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We compared the infectivity and growth rates of 12 strains of Orientia tsutsugamushi in a cell culture system. ECV304 cells were infected with O. tsutsugamushi strains for 4 hr, and the culture was maintained for 72 hr. Immunofluorescence (IF) staining was performed at 4, 24, 48, and 72 hr after inoculation (hpi), and IF-positive foci were enumerated. The AFSC-4 strain, which is known to be insensitive to doxycycline, showed higher numbers of IF-positive foci than the other 11 strains at 4, 24, 48, and 72 hpi, which may explain its apparent insensitivity to antibiotics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.