Evidence map›Paper›PMID 24475294›Full record

ArticlePloS one2014

Gene polymorphisms of micrornas in Helicobacter pylori-induced high risk atrophic gastritis and gastric cancer.

Juozas Kupcinskas, Thomas Wex, Alexander Link, Marcis Leja, Indre Bruzaite, Ruta Steponaitiene, Simonas Juzenas, Ugne Gyvyte, Audrius Ivanauskas, Guntis Ancans and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 13 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 13 syntheses or guidelines pooled it, 65 citations in OpenAlex.

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  6. Bioscience reports · 2018
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  13. Effect ofTechnology in cancer research & treatment
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  14. Article
  15. Molecular Alterations in Gastric Intestinal Metaplasia.International journal of molecular sciences · 2021
    Review
  16. Article
  17. Article
  18. A New Method for BiostatisticalJournal of healthcare engineering · 2019
    Article
  19. Small Molecules in Rare Tumors: Emerging Role of MicroRNAs in GIST.International journal of molecular sciences · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Juozas KupcinskasInstitute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania ; Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Thomas WexDepartment of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany ; Medical Laboratory for Clinical Chemistry, Microbiology and Infectious Diseases, Department of Molecular Genetics, Magdeburg, Germany.
Alexander LinkDepartment of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany.
Marcis LejaFaculty of Medicine, University of Latvia, Riga, Latvia ; Digestive Diseases Center GASTRO, Riga, Latvia ; Riga East University Hospital, Riga, Latvia.
Indre BruzaiteInstitute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Ruta SteponaitieneInstitute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Simonas JuzenasInstitute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Ugne GyvyteInstitute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Audrius IvanauskasInstitute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Guntis AncansDigestive Diseases Center GASTRO, Riga, Latvia ; Riga East University Hospital, Riga, Latvia.
Vitalija PetrenkieneDepartment of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Jurgita SkiecevicieneInstitute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Limas KupcinskasInstitute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania ; Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Peter MalfertheinerDepartment of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany.
Lithuanian University of Health Sciences · LTOtto-von-Guericke University Magdeburg · DERiga East University Hospital · LVUniversity Hospital Magdeburg · DEUniversity of Latvia · LV

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsMicroRNAs (miRNAs) are known for their function as translational regulators of tumor suppressor or oncogenes. Single nucleotide polymorphisms (SNPs) in miRNAs related genes have been shown to affect the regulatory capacity of miRNAs and were linked with gastric cancer (GC) and premalignant gastric conditions. The purpose of this study was to evaluate potential associations between miRNA-related gene polymorphisms (miR-27a, miR-146a, miR-196a-2, miR-492 and miR-608) and the presence of GC or high risk atrophic gastritis (HRAG) in European population.

methodsGene polymorphisms were analyzed in 995 subjects (controls: n = 351; GC: n = 363; HRAG: n = 281) of European descent. MiR-27a T>C (rs895819), miR-146a G>C (rs2910164), miR-196a-2 C>T (rs11614913), miR-492 G>C (rs2289030) and miR-608 C>G (rs4919510) SNPs were genotyped by RT-PCR.

resultsOverall, SNPs of miRNAs were not associated with the presence of GC or HRAG. We observed a tendency for miR-196a-2 CT genotype to be associated with higher risk of GC when compared to CC genotype, however, the difference did not reach the adjusted P-value (odds ratio (OR) - 1.46, 95% confidence interval (CI) 1.03-2.07, P = 0.032). MiR-608 GG genotype was more frequent in GC when compared to controls (OR -2.34, 95% CI 1.08-5.04), but significance remained marginal (P = 0.029). A similar tendency was observed in a recessive model for miR-608, where CC + CG vs GG genotype comparison showed a tendency for increased risk of GC with OR of 2.44 (95% CI 1.14-5.22, P = 0.021). The genotypes and alleles of miR-27a, miR-146a, miR-196a-2, miR-492 and miR-608 SNPs had similar distribution between histological subtypes of GC and were not linked with the presence of diffuse or intestinal-type GC.

conclusionsGene polymorphisms of miR-27a, miR-146a, miR-196a-2, miR-492, miR-492a and miR-608 were not associated with the presence of HRAG, GC or different histological subtypes of GC in European subjects.

Indexed as

Helicobacter pyloriGastritis, AtrophicHumansLogistic ModelsMicroRNAsOdds RatioPolymorphism, Single NucleotideStomach NeoplasmsWhite PeopleMicroRNAs

Identifiers

PMID24475294
PMCPMC3903675
OpenAlexW2146794439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.