ArticlePloS one2014
Recovery of diaphragm function following mechanical ventilation in a rodent model.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Applying lessons from limb muscle disuse and ageing to better understand ventilator-induced diaphragm dysfunction.Experimental physiology · 2025Review
- Single-nucleus transcriptomic profiling of the diaphragm during mechanical ventilation.Scientific reports · 2024Article
- Super-relaxed myosins contribute to respiratory muscle hibernation in mechanically ventilated patients.Science translational medicine · 2024Article
- Electrical stimulation mitigates muscle degradation shift in gene expressions during 12-h mechanical ventilation.Scientific reports · 2023Article
- Temporary Transvenous Diaphragmatic Neurostimulation in Prolonged Mechanically Ventilated Patients: A Feasibility Trial (RESCUE 1).Critical care explorations · 2020Article
- [Diaphragm dysfunction : Facts for clinicians].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2018Review
- Kinetics of ventilation-induced changes in diaphragmatic metabolism by bilateral phrenic pacing in a piglet model.Scientific reports · 2016Article
- Dysfunction of respiratory muscles in critically ill patients on the intensive care unit.Journal of cachexia, sarcopenia and muscle · 2016Review
- Influence of weaning methods on the diaphragm after mechanical ventilation in a rat model.BMC pulmonary medicine · 2016Article
- Respiratory weakness after mechanical ventilation is associated with one-year mortality - a prospective study.Critical care (London, England) · 2016Observational
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMechanical ventilation (MV) induces diaphragmatic muscle fiber atrophy and contractile dysfunction (ventilator induced diaphragmatic dysfunction, VIDD). It is unknown how rapidly diaphragm muscle recovers from VIDD once spontaneous breathing is restored. We hypothesized that following extubation, the return to voluntary breathing would restore diaphragm muscle fiber size and contractile function using an established rodent model.
methodsFollowing 12 hours of MV, animals were either euthanized or, after full wake up, extubated and returned to voluntary breathing for 12 hours or 24 hours. Acutely euthanized animals served as controls (each n = 8/group). Diaphragmatic contractility, fiber size, protease activation, and biomarkers of oxidative damage in the diaphragm were assessed.
results12 hours of MV induced VIDD. Compared to controls diaphragm contractility remained significantly depressed at 12 h after extubation but rebounded at 24 h to near control levels. Diaphragmatic levels of oxidized proteins were significantly elevated after MV (p = 0.002) and normalized at 24 hours after extubation.
conclusionsThese findings indicate that diaphragm recovery from VIDD, as indexed by fiber size and contractile properties, returns to near control levels within 24 hours after returning to spontaneous breathing. Besides the down-regulation of proteolytic pathways and oxidative stress at 24 hours after extubation further repairing mechanisms have to be determined.
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