ArticlePloS one2014
OsGA2ox5, a gibberellin metabolism enzyme, is involved in plant growth, the root gravity response and salt stress.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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63 citing papers in PubMed, 144 citations in OpenAlex.
- Glycine max DREB1D transcription factor regulates plant height by reducing gibberellin levels and response.Planta · 2026Article
- CRISPR/Cas9-Mediated Mutagenesis of OsERF94 Enhances Pre-Harvest Sprouting in Rice.Rice (New York, N.Y.) · 2026Article
- The Gibberellin 2-Oxidase GeneInternational journal of molecular sciences · 2026Article
- Exogenous Hormone Treatments Reveal Species-Specific Regulation of Individual Components of Root Architecture and Salt Ion Accumulation in Cultivated and Wild Tomatoes.Plant direct · 2026Article
- Genome-wide characterization and adaptive evolution of favorable gibberellin 2-oxidase alleles contributing to wheat agronomic traits.Journal of advanced research · 2026Article
- Functional Characterization ofPlants (Basel, Switzerland) · 2026Article
- Genome wide identification and expression analysis of gibberellin oxidase family genes in sweet potato and its two diploid relatives.Scientific reports · 2026Article
- Gibberellins: extending the Green Revolution.Journal of experimental botany · 2025Review
- Gibberellin Regulates LBD38-1 Responses to Xanthomonas arboricola pv. juglandis Infection in Walnut Bacterial Blight Pathogenesis.BMC genomics · 2025Article
- Reaction Mechanism of Aluminum Toxicity on Leaf Growth of Shatian Pomelo Seedlings.Plants (Basel, Switzerland) · 2025Article
- The Regulation of ROS and Phytohormones in Balancing Crop Yield and Salt Tolerance.Antioxidants (Basel, Switzerland) · 2025Review
- Over Expression of MangoInternational journal of molecular sciences · 2024Article
- The role of gibberellin synthase gene VvGA2ox7 acts as a positive regulator to salt stress in Arabidopsis thaliana.BMC plant biology · 2024Article
- Physiological and Molecular Mechanisms of Rice Tolerance to Salt and Drought Stress: Advances and Future Directions.International journal of molecular sciences · 2024Review
- Genome-Wide Analysis of the Gibberellin-Oxidases Family Members in FourInternational journal of molecular sciences · 2024Article
- A novel AP2/ERF transcription factor, NtERF10, positively regulates plant height in tobacco.Transgenic research · 2024Article
- Unraveling wheat's response to salt stress during early growth stages through transcriptomic analysis and co-expression network profiling.BMC genomic data · 2024Article
- Gibberellin 2-Oxidases in Potato (Solanum tuberosum L.): Cloning, Characterization, In Silico Analysis and Molecular Docking.Molecular biotechnology · 2024Article
- RNAi-Mediated Suppression ofInternational journal of molecular sciences · 2024Article
- Article
3 more citing papers are in PubMed but not listed here.
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6 authors at 4 institutions in 1 country.
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Abstract
Gibberellin (GA) 2-oxidases play an important role in the GA catabolic pathway through 2β-hydroxylation. There are two classes of GA2oxs, i.e., a larger class of C₁₉-GA2oxs and a smaller class of C₂₀-GA2oxs. In this study, the gene encoding a GA 2-oxidase of rice, Oryza sativa GA 2-oxidase 5 (OsGA2ox5), was cloned and characterized. BLASTP analysis showed that OsGA2ox5 belongs to the C₂₀-GA2oxs subfamily, a subfamily of GA2oxs acting on C₂₀-GAs (GA₁₂, GA₅₃). Subcellular localization of OsGA2ox5-YFP in transiently transformed onion epidermal cells revealed the presence of this protein in both of the nucleus and cytoplasm. Real-time PCR analysis, along with GUS staining, revealed that OsGA2ox5 is expressed in the roots, culms, leaves, sheaths and panicles of rice. Rice plants overexpressing OsGA2ox5 exhibited dominant dwarf and GA-deficient phenotypes, with shorter stems and later development of reproductive organs than the wild type. The dwarfism phenotype was partially rescued by the application of exogenous GA3 at a concentration of 10 µM. Ectopic expression of OsGA2ox5 cDNA in Arabidopsis resulted in a similar phenotype. Real-time PCR assays revealed that both GA synthesis-related genes and GA signaling genes were expressed at higher levels in transgenic rice plants than in wild-type rice; OsGA3ox1, which encodes a key enzyme in the last step of the bioactive GAs synthesis pathway, was highly expressed in transgenic rice. The roots of OsGA2ox5-ox plants exhibited increased starch granule accumulation and gravity responses, revealing a role for GA in root starch granule development and gravity responses. Furthermore, rice and Arabidopsis plants overexpressing OsGA2ox5 were more resistant to high-salinity stress than wild-type plants. These results suggest that OsGA2ox5 plays important roles in GAs homeostasis, development, gravity responses and stress tolerance in rice.
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