ArticlePloS one2014
Functional polymorphisms of interferon-gamma affect pneumonia-induced sepsis.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Frequency and mortality of sepsis and septic shock in China: a systematic review and meta-analysis.BMC infectious diseases · 2022Pooled it
- Effect of IFN-Y +874 T/A polymorphism on clinical manifestations of dengue: a meta-analysis.Journal of genetics · 2021Pooled it
- Immunopathological Changes in SARS-CoV-2 Critical and Non-critical Pneumonia Patients: A Systematic Review to Determine the Cause of Co-infection.Frontiers in public health · 2020Pooled it
- Decoding Host-Pathogen Dynamics inAntibiotics (Basel, Switzerland) · 2026Review
- IFNγ in human sepsis: a scoping review.Annals of intensive care · 2025Review
- Relationship Between anJournal of clinical medicine · 2025Article
- Modulation of brain immune microenvironment and cellular dynamics in systemic inflammation.Theranostics · 2025Article
- Immunogenetic Profile Associated with Patients Living with HIV-1 and Epstein-Barr Virus (EBV) in the Brazilian Amazon Region.Viruses · 2024Article
- Acute organ injury and long-term sequelae of severe pneumococcal infections.Pneumonia (Nathan Qld.) · 2023Review
- Epidemiology and clinical features of maternal sepsis: A retrospective study of whole pregnancy period.Medicine · 2022Article
- RS12574989 and haplotype associated with α/β-chain imbalance and population HbA2 reduction.BMC medical genomics · 2022Article
- Evaluating the effects of curcumin nanomicelles on clinical outcome and cellular immune responses in critically ill sepsis patients: A randomized, double-blind, and placebo-controlled trial.Frontiers in nutrition · 2022Article
- Evidence for an association of interferon gene variants with sudden infant death syndrome.International journal of legal medicine · 2019Article
- Association between IFN-γ +874 T/A (Rs2430561) Polymorphisms and Bipolar 1 Disorder: A Study in an Ethnic Iranian Population.Reports of biochemistry & molecular biology · 2019Article
- Differential Immune Phenotypes in Human Monocytes Induced by Non-Host-Adapted Salmonella enterica Serovar Choleraesuis and Host-AdaptedInfection and immunity · 2018Article
- A single nucleotide polymorphism of the interferon-γ gene and susceptibility to hepatitis B virus-related cirrhosis: a randomized controlled trial.International journal of clinical and experimental pathology · 2018Article
- Association of interferon gamma gene polymorphism and susceptibility to hepatitis C virus infection in Egyptian patients: A multicenter, family-based study.JGH open : an open access journal of gastroenterology and hepatology · 2017Article
- Variants in LTA, TNF, IL1B and IL10 genes associated with the clinical course of sepsis.Immunologic research · 2016Article
- Polymorphisms in Host Immunity-Modulating Genes and Risk of Invasive Aspergillosis: Results from the AspBIOmics Consortium.Infection and immunity · 2015Article
- CD86 polymorphism affects pneumonia-induced sepsis by decreasing gene expression in monocytes.Inflammation · 2015Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSepsis is an inflammatory syndrome caused by infection, and both its incidence and mortality are high. Because interferon-gamma (IFN-γ) plays an important role in inflammation, this work assessed IFN-γ single nucleotide polymorphism (SNPs) that may be associated with sepsis.
methodsA total of 196 patients with pneumonia-induced sepsis and 213 age- and sex-matched healthy volunteers participated in our study from July 2012 to July 2013 in Guangzhou, China. Patient clinical information was collected. Clinical pathology was assessed in subgroups defined based on clinical criteria, APACHE II (acute physiology and chronic health evaluation) and SOFA (sepsis-related organ failure assessment) scores and discharge rate. Four functional SNPs, -1616T/C (rs2069705), -764G/C (rs2069707), +874A/T (rs2430561) and +3234C/T (rs2069718), were genotyped by Snapshot in both sepsis patients and healthy controls. Pearson's chi-square test or Fisher's exact test were used to analyze the distribution of the SNPs, and the probability values (P values), odds ratios (OR) and 95% confidence intervals (CIs) were calculated.
resultsNo mutations in the IFN-γ -764G/C SNP were detected among the participants in our study. The +874A/T and +3234C/T SNPs were in strong linkage disequilibrium (LD) (r(2) = 0.894). The -1616 TC+TT, +874 AT+AA genotype and the TAC haplotype were significantly associated with sepsis susceptibility, while the CTT haplotype was associated with protection against sepsis incidence. Genotype of -1616 TT wasn't only protective against severity of sepsis, but also against higher APACHE II and SOFA scores as +874 AA and +3234 CC. The TAC haplotype was was protective against progression to severe sepsis either.
conclusionOur results suggest that functional IFN-γ SNPs and their haplotypes are associated with pneumonia-induced sepsis.
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