ArticlePloS one2014
Costs and effectiveness of treatment alternatives for proximal caries lesions.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03770286 (Treatment of Interproximal Carious Lesions on Primary Molar Teeth With SDF and Super Floss Application Versus SDF Without Super Floss Versus Fluoride Varnish Alone), which is not on this map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment of Interproximal Carious Lesions on Primary Molar Teeth With SDF and Super Floss Application Versus SDF Without Super Floss Versus Fluoride Varnish Alone: a Pilot Phase 3 Randomized Controlled Trial
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis.BMC oral health · 2021Pooled it
- A systematic review of decision analytic modeling techniques for the economic evaluation of dental caries interventions.PloS one · 2019Pooled it
- A clinical guideline for caries infiltration of proximal enamel lesions with resins.British dental journal · 2018Guideline
- Micro-invasive interventions for managing proximal dental decay in primary and permanent teeth.The Cochrane database of systematic reviews · 2015Pooled it
- Proximal carious lesions infiltration-a 3-year follow-up study of a randomized controlled clinical trial.Clinical oral investigations · 2018Trial
- Minimum Intervention Oral Care (MIOC) - Overcoming Implementation Barriers: An International Expert Consensus.International dental journal · 2026Article
- Introducing an Innovative Approach for Managing Proximal Non-Cavitated Carious Lesions in Juvenile Permanent Dentition: Combining Orthodontic Separators and Silver Fluoride Application.Medicina (Kaunas, Lithuania) · 2023Article
- Effect of Light-Curable Resin-Modified Glass Ionomer Varnish on Non-Cavitated Proximal Caries Lesions in Primary Molars: A Randomized Controlled Trial.Children (Basel, Switzerland) · 2023Article
- Resin Infiltration of Non-Cavitated Proximal Caries Lesions in Primary and Permanent Teeth: A Systematic Review and Scenario Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2023Review
- Artificial Intelligence for Caries Detection: Value of Data and Information.Journal of dental research · 2022Article
- Photobiomodulation effect of red LED (630 nm) on the free radical levels produced by pulp cells under stress conditions.Lasers in medical science · 2022Article
- Cost-effectiveness of Artificial Intelligence for Proximal Caries Detection.Journal of dental research · 2021Article
- Article
- Comparison of potential long-term costs for preventive dentistry treatment of post-orthodontic labial versus lingual enamel cavitations and esthetically relevant white-spot lesions: a simulation study with different scenarios.Head & face medicine · 2019Article
- Need of non-operative caries treatment in 16-year-olds from Northern Norway.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2019Article
- To fill or not to fill: a qualitative cross-country study on dentists' decisions in managing non-cavitated proximal caries lesions.Implementation science : IS · 2018Article
- Managing caries: the need to close the gap between the evidence base and current practice.British dental journal · 2015Article
- Detecting and treating occlusal caries lesions: a cost-effectiveness analysis.Journal of dental research · 2015Article
- Dental students' and lecturers' perception of the degree of difficulty of caries detection associated learning topics in Brazil.Journal of educational evaluation for health professions · 2015Article
- Cost-effectiveness of caries excavations in different risk groups - a micro-simulation study.BMC oral health · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesInvasive therapy of proximal caries lesions initiates a cascade of re-treatment cycles with increasing loss of dental hard tissue. Non- and micro-invasive treatment aim at delaying this cascade and may thus reduce both the health and economic burden of such lesions. This study compared the costs and effectiveness of alternative treatments of proximal caries lesions.
methodsA Markov-process model was used to simulate the events following the treatment of a proximal posterior lesion (E2/D1) in a 20-year-old patient in Germany. We compared three interventions (non-invasive; micro-invasive using resin infiltration; invasive using composite restoration). We calculated the risk of complications of initial and possible follow-up treatments and modelled time-dependent non-linear transition probabilities. Costs were calculated based on item-fee catalogues in Germany. Monte-Carlo-microsimulations were performed to compare cost-effectiveness of non- versus micro-invasive treatment and to analyse lifetime costs of all three treatments.
resultsMicro-invasive treatment was both more costly and more effective than non-invasive therapy, with ceiling-value-thresholds for willingness-to-pay between 16.73 € for E2 and 1.57 € for D1 lesions. Invasive treatment was the most costly strategy. Calculated costs and effectiveness were sensitive to lesion stage, patient's age, discounting rate and assumed initial treatment costs.
conclusionsNon- and micro-invasive treatments have lower long-term costs than invasive therapy of proximal lesions. Micro-invasive therapy had the highest cost-effectiveness for treating D1 lesions in young patients. Decision makers with a willingness-to-pay over 16.73 € and 1.57 € for E2 and D1 lesions, respectively, will find micro-invasive treatment more cost-effective than non-invasive therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.