ArticlePloS one2014
The role of viral and host microRNAs in the Aujeszky's disease virus during the infection process.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- The forecasting power of the mucin-microbiome interplay in livestock respiratory diseases.The veterinary quarterly · 2024Article
- Host miRNA and mRNA profiles during in DEF and duck after DHAV-1 infection.Scientific reports · 2024Article
- The Role of Latency-Associated Transcripts in the Latent Infection of Pseudorabies Virus.Viruses · 2022Review
- Functional Analysis of a Frontal miRNA Cluster Located in the Large Latency Transcript of Pseudorabies Virus.Viruses · 2022Article
- Expression Profiles and Interaction of MicroRNA and Transcripts in Response to Bovine Leukemia Virus Exposure.Frontiers in veterinary science · 2022Article
- MicroRNA-206 inhibits influenza A virus replication by targeting tankyrase 2.Cellular microbiology · 2021Article
- MiR&moRe2: A Bioinformatics Tool to Characterize microRNAs and microRNA-Offset RNAs from Small RNA-Seq Data.International journal of molecular sciences · 2020Article
- Cellular microRNA-155 Regulates Virus-Induced Inflammatory Response and Protects against Lethal West Nile Virus Infection.Viruses · 2019Article
- Functional analysis of prv-miR-LLT11a encoded by pseudorabies virus.Journal of veterinary science · 2019Article
- African swine fever virus does not express viral microRNAs in experimentally infected pigs.BMC veterinary research · 2018Article
- MicroRNAs and cancer: Key paradigms in molecular therapy.Oncology letters · 2018Article
- Differential expression of porcine microRNAs in African swine fever virus infected pigs: a proof-of-concept study.Virology journal · 2017Article
- MicroRNA analysis in mouse neuro-2a cells after pseudorabies virus infection.Journal of neurovirology · 2017Article
- Identification and Analysis of Novel Viral and Host Dysregulated MicroRNAs in Variant Pseudorabies Virus-Infected PK15 Cells.PloS one · 2016Article
- Evaluation of the capability of the PCV2 genome to encode miRNAs: lack of viral miRNA expression in an experimental infection.Veterinary research · 2015Article
- Identification of microRNAs in PCV2 subclinically infected pigs by high throughput sequencing.Veterinary research · 2015Article
- Current transcriptomics in pig immunity research.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Review
- MicroRNAs Expressed during Viral Infection: Biomarker Potential and Therapeutic Considerations.Biomarker insights · 2015Review
- A 2.5-kilobase deletion containing a cluster of nine microRNAs in the latency-associated-transcript locus of the pseudorabies virus affects the host response of porcine trigeminal ganglia during established latency.Journal of virology · 2015Article
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porcine production is a primary market in the world economy. Controlling swine diseases in the farm is essential in order to achieve the sector necessities. Aujeszky's disease is a viral condition affecting pigs and is endemic in many countries of the world, causing important economic losses in the swine industry. microRNAs (miRNAs) are non-coding RNAs which modulates gene expression in animals, plants and viruses. With the aim of understanding miRNA roles during the Aujeszky's disease virus [ADV] (also known as suid herpesvirus type 1 [SuHV-1]) infection, the expression profiles of host and viral miRNAs were determined through deep sequencing in SuHV-1 infected porcine cell line (PK-15) and in an animal experimental SuHV-1 infection with virulent (NIA-3) and attenuated (Begonia) strains. In the in vivo approach miR-206, miR-133a, miR-133b and miR-378 presented differential expression between virus strains infection. In the in vitro approach, most miRNAs were down-regulated in infected groups. miR-92a and miR-92b-3p were up-regulated in Begonia infected samples. Functional analysis of all this over expressed miRNAs during the infection revealed their association in pathways related to viral infection processes and immune response. Furthermore, 8 viral miRNAs were detected by stem loop RT-qPCR in both in vitro and in vivo approaches, presenting a gene regulatory network affecting 59 viral genes. Most described viral miRNAs were related to Large Latency Transcript (LLT) and to viral transcription activators EP0 and IE180, and also to regulatory genes regarding their important roles in the host-pathogen interaction during viral infection.
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