ArticlePloS one2014
Clustering HLA class I superfamilies using structural interaction patterns.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Dynamic states of an MHC class I molecule during peptide exchange.Nature communications · 2026Article
- Structural evolution of polymorphic class I HLA alleles, designating HLA-C with uncertain assemblies.Computational and structural biotechnology journal · 2026Article
- Lack of immunogenicity for an influenza-derived peptide across the HLA-B44 supertype molecules.Clinical & translational immunology · 2025Article
- The Prognostic Significance of Selected HLA Alleles on Prostate Cancer Outcome.International journal of molecular sciences · 2023Article
- Predicted impact of the viral mutational landscape on the cytotoxic response against SARS-CoV-2.PLoS computational biology · 2022Article
- The pockets guide to HLA class I molecules.Biochemical Society transactions · 2021Review
- Neoantigen vaccination induces clinical and immunologic responses in non-small cell lung cancer patients harboring EGFR mutations.Journal for immunotherapy of cancer · 2021Article
- Pharmacogenetic and Association Studies on the Influence of HLA Alleles and Rivastigmine on the Iranian Patients with Late-Onset Alzheimer's Disease.Molecular neurobiology · 2021Article
- Global analysis of shared T cell specificities in human non-small cell lung cancer enables HLA inference and antigen discovery.Immunity · 2021Article
- Integrative Analysis of HTNV Glycoprotein Derived MHC II Epitopes byFrontiers in cellular and infection microbiology · 2021Article
- Sequence-structure-function relationships in class I MHC: A local frustration perspective.PloS one · 2020Article
- How an alloreactive T-cell receptor achieves peptide and MHC specificity.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Observational
- HLA superfamily assignment is a predictor of immune response to cancer testis antigens and survival in ovarian cancer.Gynecologic oncology · 2016Article
- Deciphering complex patterns of class-I HLA-peptide cross-reactivity via hierarchical grouping.Immunology and cell biology · 2015Article
- The ultimate mix and match: making sense of HLA alleles and peptide repertoires.Immunology and cell biology · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human leukocyte antigen (HLA) class I molecules are critical components of the cell-mediated immune system that bind and present intracellular antigenic peptides to CD8(+) T cell receptors. To understand the interaction mechanism underlying human leukocyte antigen (HLA) class I specificity in detail, we studied the structural interaction characteristics of 16,393 nonameric peptides binding to 58 HLA-A and -B molecules. Our analysis showed for the first time that HLA-peptide intermolecular bonding patterns vary among different alleles and may be grouped in a superfamily dependent manner. Through the use of these HLA class I 'fingerprints', a high resolution HLA class I superfamily classification schema was developed. This classification is capable of separating HLA alleles into well resolved, non-overlapping clusters, which is consistent with known HLA superfamily definitions. Such structural interaction approach serves as an excellent alternative to the traditional methods of HLA superfamily definitions that use peptide binding motifs or receptor information, and will help identify appropriate antigens suitable for broad-based subunit vaccine design.
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