ArticlePloS one2014
ASDCD: antifungal synergistic drug combination database.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 84 citations in OpenAlex.
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- Combined Application of Tacrolimus with Cyproconazole, Hymexazol and Novel {2-(3-R-1Journal of fungi (Basel, Switzerland) · 2023Article
- CDCDB: A large and continuously updated drug combination database.Scientific data · 2022Article
- Machine learning methods, databases and tools for drug combination prediction.Briefings in bioinformatics · 2022Article
- ACDB: An Antibiotic Combination DataBase.Frontiers in pharmacology · 2022Article
- Machine learning approaches for drug combination therapies.Briefings in bioinformatics · 2021Review
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- Combination Therapy to Treat Fungal Biofilm-Based Infections.International journal of molecular sciences · 2020Review
- DrugCombDB: a comprehensive database of drug combinations toward the discovery of combinatorial therapy.Nucleic acids research · 2020Article
- Synergistic drug combinations prediction by integrating pharmacological data.Synthetic and systems biotechnology · 2019Article
- CANCROX: a cross-species cancer therapy database.Database : the journal of biological databases and curation · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Finding effective drugs to treat fungal infections has important clinical significance based on high mortality rates, especially in an immunodeficient population. Traditional antifungal drugs with single targets have been reported to cause serious side effects and drug resistance. Nowadays, however, drug combinations, particularly with respect to synergistic interaction, have attracted the attention of researchers. In fact, synergistic drug combinations could simultaneously affect multiple subpopulations, targets, and diseases. Therefore, a strategy that employs synergistic antifungal drug combinations could eliminate the limitations noted above and offer the opportunity to explore this emerging bioactive chemical space. However, it is first necessary to build a powerful database in order to facilitate the analysis of drug combinations. To address this gap in our knowledge, we have built the first Antifungal Synergistic Drug Combination Database (ASDCD), including previously published synergistic antifungal drug combinations, chemical structures, targets, target-related signaling pathways, indications, and other pertinent data. Its current version includes 210 antifungal synergistic drug combinations and 1225 drug-target interactions, involving 105 individual drugs from more than 12,000 references. ASDCD is freely available at http://ASDCD.amss.ac.cn.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.