ArticlePloS one2014
BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 59 citations in OpenAlex.
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- One BAG Does Not Fit All: Differences and Similarities of BAG Family Members in Mediating Central Nervous System Homeostasis.Biological psychiatry · 2025Review
- Next Generation Sequencing and Electromyography Reveal the Involvement of theCurrent issues in molecular biology · 2024Article
- Identification of candidate mitochondrial inheritance determinants using the mammalian cell-free system.eLife · 2023Article
- BAG family proteins contributes to autophagy-mediated multidrug resistance of tumor.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022Review
- Mitochondria in neurodegeneration.Current opinion in physiology · 2022Article
- Review
- Identification of BAG5 as a Potential Biomarker for Parkinson's Disease Patients With R492XFrontiers in neuroscience · 2022Article
- Role of BAG5 in Protein Quality Control: Double-Edged Sword?Frontiers in aging · 2022Review
- Precise control of mitophagy through ubiquitin proteasome system and deubiquitin proteases and their dysfunction in Parkinson's disease.BMB reports · 2021Article
- Cleaved PINK1 induces neuronal plasticity through PKA-mediated BDNF functional regulation.Journal of neuroscience research · 2021Article
- miRNA-770-5p expression is upregulated in patients with type 2 diabetes and miRNA-770-5p knockdown protects pancreatic β-cell function via targeting BAG5 expression.Experimental and therapeutic medicine · 2021Article
- Regulation of Parkin-dependent mitophagy by Bcl-2-associated athanogene (BAG) family members.Neural regeneration research · 2021Article
- The Mitochondrial Kinase PINK1 in Diabetic Kidney Disease.International journal of molecular sciences · 2021Review
- PINK1: Multiple mechanisms of neuroprotection.International review of movement disorders · 2021Article
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- Article
- Dependence of PINK1 accumulation on mitochondrial redox system.Aging cell · 2020Article
- Human telomerase reverse transcriptase positively regulates mitophagy by inhibiting the processing and cytoplasmic release of mitochondrial PINK1.Cell death & disease · 2020Article
- Chronic treatment with the complex I inhibitor MPPThe Journal of biological chemistry · 2020Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations in PTEN-induced kinase 1 (PINK1) gene cause PARK6 familial Parkinsonism, and loss of the stability of PINK1 may also contribute to sporadic Parkinson's disease (PD). Degradation of PINK1 occurs predominantly through the ubiquitin proteasome system (UPS), however, to date, few of the proteins have been found to regulate the degradation of PINK1. Using the yeast two-hybrid system and pull-down methods, we identified bcl-2-associated athanogene 5 (BAG5), a BAG family member, directly interacted with PINK1. We showed that BAG5 stabilized PINK1 by decreasing the ubiquitination of PINK1. Interestingly, BAG5 rescued MPP(+)- and rotenone-induced mitochondria dysfunction by up-regulating PINK1 in vitro. In PINK1-null mice and MPTP-treated mice, BAG5 significantly increased in the substantia nigra pars compacta (SNpc) although PINK1 was decreased. Our findings indicated that BAG5, as a key protein to stabilize PINK1, is a promising therapeutic tool for preventing mitochondrial dysfunction following oxidative stress.
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