ArticleMolecular and cellular biology1988
Sequence and expression of a type II keratin, K5, in human epidermal cells.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 75 citations in OpenAlex.
- Directed expression of a chimeric type II keratin partially rescues keratin 5-null mice.The Journal of biological chemistry · 2014Article
- Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia.The Journal of cell biology · 2011Review
- "Panta rhei": Perpetual cycling of the keratin cytoskeleton.Bioarchitecture · 2011Article
- Overexpression of constitutively active BMP-receptor-IB in mouse skin causes an ichthyosis-vulgaris-like disease.Cell and tissue research · 2010Article
- Transgenic mice exhibiting inducible and spontaneous Cre activities driven by a bovine keratin 5 promoter that can be used for the conditional analysis of basal epithelial cells in multiple organs.Journal of biomedical science · 2009Article
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- MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis.The EMBO journal · 2000Article
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- Differential expression of cytokeratin mRNA and protein in normal prostate, prostatic intraepithelial neoplasia, and invasive carcinoma.The American journal of pathology · 1997Article
- Probing keratinocyte and differentiation specificity of the human K5 promoter in vitro and in transgenic mice.Molecular and cellular biology · 1993Article
- Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice.The EMBO journal · 1993Article
- Transgenic overexpression of transforming growth factor alpha bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis.Molecular and cellular biology · 1992Article
- Elucidating the early stages of keratin filament assembly.The Journal of cell biology · 1990Article
- Human oral epithelial cell culture. II. Keratin expression in fetal and adult gingival cells.In vitro cellular & developmental biology : journal of the Tissue Culture Association · 1990Article
- Keratins as markers that distinguish normal and tumor-derived mammary epithelial cells.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control.Molecular and cellular biology · 1989Article
- The use of retinoic acid to probe the relation between hyperproliferation-associated keratins and cell proliferation in normal and malignant epidermal cells.The Journal of cell biology · 1989Article
- Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation.The Journal of cell biology · 1988Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report here the cDNA and amino acid sequences of a human 58-kilodalton type II keratin, K5, which is coexpressed with a 50-kilodalton type I keratin partner, K14, in stratified squamous epithelia. Using a probe specific for the 3'-noncoding portion of this K5 cDNA, we demonstrated the existence of a single human gene encoding this sequence. Using Northern (RNA) blot analysis and in situ hybridization with cRNA probes for both K5 and K14, we examined the expression of these mRNAs in the epidermis and in cultured epidermal cells. Our results indicate that the mRNAs for K5 and K14 are coordinately expressed and abundant in the basal layer of the epidermis. As cells undergo a commitment to terminally differentiate, the expression of both mRNAs seems to be downregulated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.