ArticleProceedings of the National Academy of Sciences of the United States of America2014
Assessing mucociliary transport of single particles in vivo shows variable speed and preference for the ventral trachea in newborn pigs.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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Who cites it
41 citing papers in PubMed, 70 citations in OpenAlex.
- Particle size determines mucociliary transport mechanisms in normal and cystic fibrosis airways.bioRxiv : the preprint server for biology · 2026Article
- Development and Initial Characterization of Pigs withbioRxiv : the preprint server for biology · 2024Article
- INSIGHTS INTO THE ORIGINS OF CYSTIC FIBROSIS LUNG DISEASE.Transactions of the American Clinical and Climatological Association · 2024Review
- Goblet cell interactions reorient bundled mucus strands for efficient airway clearance.PNAS nexus · 2023Article
- Pseudomonas aeruginosa type IV pili actively induce mucus contraction to form biofilms in tissue-engineered human airways.PLoS biology · 2023Article
- Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis piglets.Respiratory research · 2023Article
- Disturbing the Spatial Organization of Biofilm Communities Affects Expression ofApplied and environmental microbiology · 2023Article
- Tromethamine improves mucociliary clearance in cystic fibrosis pigs.Physiological reports · 2022Article
- Cell shape controls rheotaxis in small parasitic bacteria.PLoS pathogens · 2022Article
- Elastic mucus strands impair mucociliary clearance in cystic fibrosis pigs.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Periodically Disturbing the Spatial Structure of Biofilms Can Affect the Production of an Essential Virulence Factor inmSystems · 2021Article
- Combined agonists act synergistically to increase mucociliary clearance in a cystic fibrosis airway model.Scientific reports · 2021Article
- Dorso-ventral heterogeneity in tracheal basal stem cells.Biology open · 2021Article
- Cell-mimicking nanodecoys neutralize SARS-CoV-2 and mitigate lung injury in a non-human primate model of COVID-19.Nature nanotechnology · 2021Article
- Ivacaftor Reverses Airway Mucus Abnormalities in a Rat Model Harboring a Humanized G551D-CFTR.American journal of respiratory and critical care medicine · 2020Article
- Article
- Molecular interactions between Neisseria meningitidis and its human host.Cellular microbiology · 2019Review
- Particle coating alters mucociliary transit in excised rat trachea: A synchrotron X-ray imaging study.Scientific reports · 2019Article
- Assembly, Release, and Transport of Airway Mucins in Pigs and Humans.Annals of the American Thoracic Society · 2018Review
- Mucociliary Transport in Healthy and Cystic Fibrosis Pig Airways.Annals of the American Thoracic Society · 2018Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Mucociliary transport (MCT) is an innate defense mechanism that removes particulates, noxious material, and microorganisms from the lung. Several airway diseases exhibit abnormal MCT, including asthma, chronic bronchitis, and cystic fibrosis. However, it remains uncertain whether MCT abnormalities contribute to the genesis of disease or whether they are secondary manifestations that may fuel disease progression. Limitations of current MCT assays and of current animal models of human disease have hindered progress in addressing these questions. Therefore, we developed an in vivo assay of MCT, and here we describe its use in newborn wild-type pigs. We studied pigs because they share many physiological, biochemical, and anatomical features with humans and can model several human diseases. We used X-ray multidetector-row-computed tomography to track movement of individual particles in the large airways of newborn pigs. Multidetector-row-computed tomography imaging provided high spatial and temporal resolution and registration of particle position to airway anatomy. We discovered that cilia orientation directs particles to the ventral tracheal surface. We also observed substantial heterogeneity in the rate of individual particle movement, and we speculate that variations in mucus properties may be responsible. The increased granularity of MCT data provided by this assay may provide an opportunity to better understand host defense mechanisms and the pathogenesis of airway disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.