ArticleProceedings of the National Academy of Sciences of the United States of America2014
Lateral organ boundaries 1 is a disease susceptibility gene for citrus bacterial canker disease.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers.
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Who cites it
158 citing papers in PubMed.
- Xanthomonas effectors: nutritional hijacking for a long running battle.Pest management science · 2026Review
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- Control Targets in Plant-Pathogenic Bacteria: From Growth-Essential Processes to Anti-Virulence Strategies and Candidate Targets inPlants (Basel, Switzerland) · 2026Review
- Genome-wide identification and expression analysis of the LBD gene family in Jasminum sambac.Scientific reports · 2026Article
- Guardians or Gateways? The Intricate Relationship Between Plant Cell Walls and Pathogenic Xanthomonas.Molecular plant pathology · 2026Review
- Integrative analysis of sulfate transporters in Citrus sinensis reveals CsSULTR3;5 involved in pathogen stress response.Journal, genetic engineering & biotechnology · 2026Article
- An Ustilaginoidea virens Nuclear Effector SCRE7 Inhibits Rice Immunity via Suppressing OsLBD11/12-Promoted Transcription of OsCPS2.Plant biotechnology journal · 2026Article
- Cas9/sgRNA-mediated genome editing of citrus via mature tissue transformation enables both high-efficacy genome editing and early flowering.Frontiers in plant science · 2026Article
- Root-exuded sugars as drivers of rhizosphere microbiome assembly.Plant biotechnology (Tokyo, Japan) · 2025Article
- Transcription activator-like effectors of Xanthomonas oryzae pv. oryzae hijack host transcriptional regulation through OsWRKYs.Journal of integrative plant biology · 2025Article
- Stripe rust fungi hijack a host transcriptional repressor to induce TaSWEET14d for enhanced sugar uptake in wheat.Science advances · 2025Article
- Using targeted genome methylation for crop improvement.Journal of experimental botany · 2025Review
- Gibberellin Regulates LBD38-1 Responses to Xanthomonas arboricola pv. juglandis Infection in Walnut Bacterial Blight Pathogenesis.BMC genomics · 2025Article
- Two TAL effectors of Xanthomonas citri promote pustule formation by directly repressing the expression of GRAS transcription factor in citrus.Molecular horticulture · 2025Article
- Origin and de novo domestication of sweet orange.Nature genetics · 2025Article
- Sugar transporters: mediators of carbon flow between plants and microbes.Frontiers in plant science · 2025Review
- Genomics in plant pathogen identification and control.Frontiers in plant science · 2025Review
- Identifying the role of cellulase geneMolecular breeding : new strategies in plant improvement · 2025Article
- Transcriptomic analysis reveals differential transcriptional regulation underlying Citrus Bacterial Canker (CBC) tolerance in Citrus sinensis.BMC genomics · 2024Article
98 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Citrus bacterial canker (CBC) disease occurs worldwide and incurs considerable costs both from control measures and yield losses. Bacteria that cause CBC require one of six known type III transcription activator-like (TAL) effector genes for the characteristic pustule formation at the site of infection. Here, we show that Xanthomonas citri subspecies citri strain Xcc306, with the type III TAL effector gene pthA4 or with the distinct yet biologically equivalent gene pthAw from strain XccA(w), induces two host genes, CsLOB1 and CsSWEET1, in a TAL effector-dependent manner. CsLOB1 is a member of the Lateral Organ Boundaries (LOB) gene family of transcription factors, and CsSWEET1 is a homolog of the SWEET sugar transporter and rice disease susceptibility gene. Both TAL effectors drive expression of CsLOB1 and CsSWEET1 promoter reporter gene fusions when coexpressed in citrus or Nicotiana benthamiana. Artificially designed TAL effectors directed to sequences in the CsLOB1 promoter region, but not the CsSWEET1 promoter, promoted pustule formation and higher bacterial leaf populations. Three additional distinct TAL effector genes, pthA*, pthB, and pthC, also direct pustule formation and expression of CsLOB1. Unlike pthA4 and pthAw, pthB and pthC do not promote the expression of CsSWEET1. CsLOB1 expression was associated with the expression of genes associated with cell expansion. The results indicate that CBC-inciting species of Xanthomonas exploit a single host disease susceptibility gene by altering the expression of an otherwise developmentally regulated gene using any one of a diverse set of TAL effector genes in the pathogen populations.
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