ArticleProceedings of the National Academy of Sciences of the United States of America2014
Site-specific targeting of enterovirus capsid by functionalized monodisperse gold nanoclusters.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 109 citations in OpenAlex.
- Unlocking the potential of gold nanoparticles with insights into green synthesis, mechanisms, characterization and multifunctional applications.Discover nano · 2026Review
- Fabrication of polyvinylpyrrolidone capped nickel nanoclusters as sensing material for enhanced electrocatalytic oxidation of 2-amino-4-chlorophenol.RSC advances · 2025Article
- Review
- Buckling cluster-based H-bonded icosahedral capsules and their propagation to a robust zeolite-like supramolecular framework.Nature communications · 2024Article
- Thermodynamic Characterization of the Interaction of Biofunctionalized Gold Nanoclusters with Serum Albumin Using Two- and Three-Dimensional Methods.International journal of molecular sciences · 2023Article
- Covalent and non-covalent coupling of a AuNanoscale advances · 2021Article
- Applications of nanotechnology in virus detection, tracking, and infection mechanisms.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2021Review
- Nanotechnology-based approaches for emerging and re-emerging viruses: Special emphasis on COVID-19.Microbial pathogenesis · 2021Review
- Prospects and challenges for computer simulations of monolayer-protected metal clusters.Nature communications · 2021Article
- Single-Virus Tracking: From Imaging Methodologies to Virological Applications.Chemical reviews · 2020Review
- Assembly of gold nanoparticles using turnip yellow mosaic virus as an in-solution SERS sensor.RSC advances · 2019Article
- A method for structure prediction of metal-ligand interfaces of hybrid nanoparticles.Nature communications · 2019Article
- Nano-based approach to combat emerging viral (NIPAH virus) infection.Nanomedicine : nanotechnology, biology, and medicine · 2019Review
- (Meta-)stability and Core-Shell Dynamics of Gold Nanoclusters at Finite Temperature.The journal of physical chemistry letters · 2019Article
- Structural characterization of site-modified nanocapsid with monodispersed gold clusters.Scientific reports · 2017Article
- Surface modulatable nanocapsids for targeting and tracking toward nanotheranostic delivery.Pharmaceutical patent analyst · 2016Review
- Conformation and dynamics of the ligand shell of a water-soluble Au102 nanoparticle.Nature communications · 2016Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Development of precise protocols for accurate site-specific conjugation of monodisperse inorganic nanoparticles to biological material is one of the challenges in contemporary bionanoscience and nanomedicine. We report here a successful site-specific covalent conjugation of functionalized atomically monodisperse gold clusters with 1.5-nm metal cores to viral surfaces. Water-soluble Au102(para-mercaptobenzoic acid)44 clusters, functionalized by maleimide linkers to target cysteines of viral capsid proteins, were synthesized and conjugated to enteroviruses echovirus 1 and coxsackievirus B3. Quantitative analysis of transmission electron microscopy images and the known virus structures showed high affinity and mutual ordering of the bound gold clusters on the viral surface and a clear correlation between the clusters and the targeted cysteine sites close to the viral surface. Infectivity of the viruses was not compromised by loading of several tens of gold clusters per virus. These advances allow for future investigations of the structure-function relations of enteroviruses and enterovirus-related virus-like particles, including their entry mechanisms into cells and uncoating in cellular endosomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.