Evidence map›Paper›PMID 24474583›Full record

SynthesisKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2015

Non-steroidal anti-inflammatory drugs (NSAIDs) for treating acute ankle sprains in adults: benefits outweigh adverse events.

Michel P J van den Bekerom, Arnout Sjer, Matthijs P Somford, Gythe H Bulstra, Peter A A Struijs, Gino M M J Kerkhoffs

Open access · greenAbstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. The impact of ankle kinesio taping on pain management in patients with acute ankle sprain.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2024
    Trial
  4. Trial
  5. Trial
  6. Trial
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Reparative and Maladaptive Inflammation in Tendon Healing.Frontiers in bioengineering and biotechnology · 2021
    Review
  16. Review
  17. Return to Play After a Lateral Ligament Ankle Sprain.Current reviews in musculoskeletal medicine · 2020
    Review
  18. Article
  19. Review
  20. There is no simple lateral ankle sprain.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Michel P J van den BekeromOLVG, Amsterdam, The Netherlands. Bekerom@gmail.com.
Arnout SjerMCA, Alkmaar, The Netherlands.
Matthijs P SomfordAmphia hospital, Breda, The Netherlands.
Gythe H BulstraOLVG, Amsterdam, The Netherlands.
Peter A A StruijsAMC, Amsterdam, The Netherlands.
Gino M M J KerkhoffsAMC, Amsterdam, The Netherlands.
OLVG · NLAmphia Ziekenhuis · NLMedisch Centrum Alkmaar · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn the recent clinical guideline for acute lateral ankle sprain, the current best evidence for diagnosis, treatment and prevention strategies was evaluated. Key findings for treatment included the use of ice and compression in the initial phase of treatment, in combination with rest and elevation. A short period of taking non-steroidal anti-inflammatory drugs (NSAIDs) may facilitate a rapid decrease in pain and swelling can also be helpful in the acute phase. The objective was to assess the effectiveness and safety of oral and topical NSAID in the treatment for acute ankle sprains.

methodsRandomised controlled trials comparing oral or topic NSAID treatment with placebo or each other were included. Primary outcome measures were pain at rest or at mobilisation and adverse events. Trials were assessed using the Cochrane risk of bias tool.

resultsTwenty-eight studies were included, and 22 were available for meta-analysis. Superior results were reported for oral NSAIDs when compared with placebo, concerning pain on weight bearing on short term, pain at rest on the short term, and less swelling on short- and intermediate term. For topical NSAIDs, superior results compared with placebo were found for pain at rest (short term), persistent pain (intermediate term), pain on weight bearing (short- and intermediate term) and for swelling (short and intermediate term). No trials were included comparing oral with topic NSAIDs, so conclusions regarding this comparison are not realistic.

conclusionsThe current evidence is limited due to the low number of studies, lack of methodological quality of the included studies as well as the small sample size of the included studies. Nevertheless, the findings from this review support the use of NSAIDs for the initial treatment for acute ankle sprains. LEVEL OF EVIDENCE: Meta-analysis of RCTs, Level I.

Indexed as

Administration, OralAdministration, TopicalAdultAnkle InjuriesAnti-Inflammatory Agents, Non-SteroidalArthralgiaHumansRandomized Controlled Trials as TopicSprains and StrainsAnti-Inflammatory Agents, Non-Steroidal

Identifiers

PMID24474583
OpenAlexW2088790326

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.